Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.

doi:10.4155/fmc.15.169

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.
	Huang, Ren-Yong 1; Chen, Wen-Ting 1; Kurtan, Tibor 2; Mandi, Attila 2; Ding, Jian1 ; Li, Jia1 ; Li, Xu-Wen1 ; Guo, Yue-Wei1
刊名	FUTURE MEDICINAL CHEMISTRY
	2016
卷号	8 期号:1 页码:17-27
关键词	epimer NF-kappa B signaling pathway TDDFT ECD tetrahydroisoquinolinequinone
ISSN号	1756-8919
DOI	10.4155/fmc.15.169
文献子类	Article
英文摘要	Background: Nudibranchs are slug-like invertebrates, well known as rich sources of biologically active secondary metabolites with highly chemical diversity and complexity. The production of such interesting metabolites was possibly influenced by their diet relationship with sponges such as Xestospongia. Results: Our continuous investigation of South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. led to the isolation of two new and eight known metabolites (1-10). The absolute configurations were determined by time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) method and by the comparison of ECD spectra. In bioassays, 1-4 and 7 showed strong NF-kappa B inhibitory activity, 4-6 exhibited considerable cytotoxicity against A549 and HL-60 tumor cell lines. Conclusion: Five unusual isoquinolinequinones (3, 7-10) were discovered from both two animals, further confirmed their predator-prey relationship. Preliminary bioassay results and structure-activity relationship studies suggested that several isolated compounds were potential to be drug leads.
资助项目	National Marine '863' Projects[2013AA092902] ; National Marine '863' Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41476063] ; NSFC Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] ; Hungarian National Research Foundation[OTKA K105871]
WOS关键词	KAPPA-B ; SIGNALING PATHWAY ; MECHANISMS ; ASSAY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FUTURE SCI LTD
WOS记录号	WOS:000367193900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276274]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Xu-Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary
推荐引用方式 GB/T 7714	Huang, Ren-Yong,Chen, Wen-Ting,Kurtan, Tibor,et al. Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.[J]. FUTURE MEDICINAL CHEMISTRY,2016,8(1):17-27.
APA	Huang, Ren-Yong.,Chen, Wen-Ting.,Kurtan, Tibor.,Mandi, Attila.,Ding, Jian.,...&Guo, Yue-Wei.(2016).Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp..FUTURE MEDICINAL CHEMISTRY,8(1),17-27.
MLA	Huang, Ren-Yong,et al."Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.".FUTURE MEDICINAL CHEMISTRY 8.1(2016):17-27.