New alkaloids from Daphniphyllum himalense

doi:10.1039/c6ra06420e

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	New alkaloids from Daphniphyllum himalense
	Zhang, Hua 1; Zhang, Dong-Dong 1; Li, Jing-Ya1 ; Shyaula, Sajan L.2; Li, Jia1 ; Yue, Jian-Min1
刊名	RSC ADVANCES
	2016
卷号	6 期号:50 页码:44402-44409
ISSN号	2046-2069
DOI	10.1039/c6ra06420e
文献子类	Article
英文摘要	Nine new Daphniphyllum alkaloids (1-9) and 16 biosynthetically related known ones were obtained during the phytochemical investigation into a Nepalese plant, Daphniphyllum himalense. Structures were assigned to these compounds based on careful spectroscopic interpretation and NMR comparison with literature data. Deuteration of H-2-16 in CD3OD due to quick keto-enol tautomerization was observed for both 2 and 3. The recently reported 3 beta-hydroxydaphniyunnine A was re-examined and its structure was revised to be 21-deoxymacropodumine D via X-ray diffraction analysis. All the isolates were screened preliminarily for their in vitro inhibitory effects against four kinases, PTP1B, aurora A, HDAC6 and IKK-beta, and selective alkaloids exhibited weak activities at 20 mu g mL(-1).
资助项目	National Natural Science Foundation of P. R. China[81322045]
WOS关键词	MACROPODUM MIQ ; A-C ; LONGERACEMOSUM ; PAXIANUM ; SKELETON ; BARK
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000376119000066
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276227]
专题	天然药物化学研究室中科院受体结构与功能重点实验室期刊编辑部新药研究国家重点实验室分析化学研究室
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Nepal Acad Sci & Technol, GPO Box 3323, Kathmandu, Nepal
推荐引用方式 GB/T 7714	Zhang, Hua,Zhang, Dong-Dong,Li, Jing-Ya,et al. New alkaloids from Daphniphyllum himalense[J]. RSC ADVANCES,2016,6(50):44402-44409.
APA	Zhang, Hua,Zhang, Dong-Dong,Li, Jing-Ya,Shyaula, Sajan L.,Li, Jia,&Yue, Jian-Min.(2016).New alkaloids from Daphniphyllum himalense.RSC ADVANCES,6(50),44402-44409.
MLA	Zhang, Hua,et al."New alkaloids from Daphniphyllum himalense".RSC ADVANCES 6.50(2016):44402-44409.