Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity

doi:10.1016/j.bmcl.2015.12.097

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	Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity
	Zhang, Li 2; Jiang, Cheng-Shi 1,2; Gao, Li-Xin 2; Gong, Jing-Xu 2; Wang, Zhong-Hua 3; Li, Jing-Ya2 ; Li, Jia2 ; Li, Xu-Wen2 ; Guo, Yue-Wei2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016-02-01
卷号	26 期号:3 页码:778-781
关键词	Phidianidine Oxadiazole derivative PTP1B inhibitor Specific selectivity Docking analysis Function-oriented synthesis
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2015.12.097
文献子类	Article
英文摘要	A series of phidianidine B derivatives were synthesized by introducing various heterocyclic rings. Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated. A majority of them displayed significant inhibitory potency and specific selectivity over PTP1B. The SAR and molecular docking analysis were also described. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Marine "863" Projects[2013AA092902] ; National Marine "863" Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; SCTSM Project[15431901000] ; SCTSM Project[14431901100] ; NSFC Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] ; "Youth Innovation Promotion Association" from Chinese Academy of Sciences[00000000] ; "Young Talent Supporting Project" from China Association for Science and Technology[00000000]
WOS关键词	PROTEIN-TYROSINE-PHOSPHATASE ; BIOLOGICAL EVALUATION ; INSULIN SENSITIVITY ; INDOLE ALKALOIDS ; 1B INHIBITORS ; RESISTANCE ; MICE
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000368797600016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276168]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Univ Jinan, Sch Biol Sci & Technol, 336 Nan Xin Zhuang Xi Rd, Jinan 250022, Shandong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Hai Quan Rd, Shanghai 201418, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Li,Jiang, Cheng-Shi,Gao, Li-Xin,et al. Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(3):778-781.
APA	Zhang, Li.,Jiang, Cheng-Shi.,Gao, Li-Xin.,Gong, Jing-Xu.,Wang, Zhong-Hua.,...&Guo, Yue-Wei.(2016).Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(3),778-781.
MLA	Zhang, Li,et al."Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.3(2016):778-781.