Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells

doi:10.1016/j.canlet.2015.12.029

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	Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells
	Zhang, Yuanyuan 1,2; Wang, Yuqi 2; Wei, Youheng 2; Wu, Jiaxue 2; Zhang, Pingzhao 2; Shen, Suqin 2; Saiyin, Hexige 2; Wumaier, Reziya 2; Yang, Xianmei 2; Wang, Chenji 2
刊名	CANCER LETTERS
	2016-03-01
卷号	372 期号:1 页码:101-109
关键词	Chaperonin CCT3 Hepatocellular carcinoma Microtubule Vincristine
ISSN号	0304-3835
DOI	10.1016/j.canlet.2015.12.029
文献子类	Article
英文摘要	CCT3 was one of the subunits of molecular chaperone CCT/TRiC complex, which plays a central role in maintaining cellular proteostasis. We demonstrated that expressions of CCT3 mRNA and protein are highly up-regulated in hepatocellular carcinoma (HCC) tissues, and high level of CCT3 is correlated with poor survival in cancer patients. In HCC cell lines, CCT3 depletion suppresses cell proliferation by inducing mitotic arrest at prometaphase and apoptosis eventually. We also identified CCT3 as a novel regulator of spindle integrity and as a requirement for proper kinetochore-microtubule attachment during mitosis. Moreover, we found that CCT3 depletion sensitizes HCC cells to microtubule destabilizing drug Vincristine. Collectively, our study suggests that CCT3 is indispensible for HCC cell proliferation, and provides a potential drug target for treatment of HCC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81472567] ; National Natural Science Foundation of China[31301202] ; National Natural Science Foundation of China[81171964]
WOS关键词	CYTOSOLIC CHAPERONIN ; CYTOSKELETAL ORGANIZATION ; CYTOPLASMIC CHAPERONIN ; CYCLE PROGRESSION ; COMPLEX ; TUBULIN ; CANCER ; EXPRESSION ; SUBUNITS ; TARGET
WOS研究方向	Oncology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000370832600011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276129]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Chenji; Yu, Long
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, 2005 Songhu Rd, Shanghai 200433, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Yuanyuan,Wang, Yuqi,Wei, Youheng,et al. Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells[J]. CANCER LETTERS,2016,372(1):101-109.
APA	Zhang, Yuanyuan.,Wang, Yuqi.,Wei, Youheng.,Wu, Jiaxue.,Zhang, Pingzhao.,...&Yu, Long.(2016).Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.CANCER LETTERS,372(1),101-109.
MLA	Zhang, Yuanyuan,et al."Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells".CANCER LETTERS 372.1(2016):101-109.