The asymmetric total synthesis of (+)-salvianolic acid A

doi:10.1016/j.tet.2016.05.070

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	The asymmetric total synthesis of (+)-salvianolic acid A
	Zheng, Yong; Song, Wei-Bin; Xuan, Li-Jiang
刊名	TETRAHEDRON
	2016-08-18
卷号	72 期号:33 页码:5047-5050
关键词	Asymmetric addition Aryl metal reagents Phenyl-D-lactic acid C-H activation Salvianolic acid A
ISSN号	0040-4020
DOI	10.1016/j.tet.2016.05.070
文献子类	Article
英文摘要	An asymmetric synthesis of (+)-salvianolic acid A with cardioprotective properties, has been accomplished in a convergent manner in eight steps and 10.6% overall yield. This synthesis features an asymmetric addition of organometallics to optically pure 2,3-epoxypropionate in the presence of BF3 center dot Et2O, Ru(III)-catalyzed directed C-H olefination, and I-2-catalyzed isomerization reaction. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[SIMM1601ZZ-03] ; China Postdoctoral Science Foundation[2014M550257]
WOS关键词	SALVIANOLIC ACID ; (+)-LITHOSPERMIC ACID ; BIOLOGICAL EVALUATION ; ENANTIOSELECTIVE REDUCTION ; ROUTE ; DERIVATIVES ; ACTIVATION ; INHIBITOR ; KETONES ; ESTERS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000381170600006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275925]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xuan, Li-Jiang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yong,Song, Wei-Bin,Xuan, Li-Jiang. The asymmetric total synthesis of (+)-salvianolic acid A[J]. TETRAHEDRON,2016,72(33):5047-5050.
APA	Zheng, Yong,Song, Wei-Bin,&Xuan, Li-Jiang.(2016).The asymmetric total synthesis of (+)-salvianolic acid A.TETRAHEDRON,72(33),5047-5050.
MLA	Zheng, Yong,et al."The asymmetric total synthesis of (+)-salvianolic acid A".TETRAHEDRON 72.33(2016):5047-5050.