Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum

doi:10.1021/acs.orglett.6b02132

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	Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum
	Tang, Yu 1; Xiong, Juan 1; Zhang, Jing-Jing 2; Wang, Wei 2; Zhang, Hai-Yan2 ; Hu, Jin-Feng 1
刊名	ORGANIC LETTERS
	2016-09-02
卷号	18 期号:17 页码:4376-4379
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b02132
文献子类	Article
英文摘要	Three novel 7,8-seco-lycopodane-derived 8,5-lactones (annotinolides A-C, 1-3) were isolated from Lycopodium annotinum. Their structures were elucidated by spectroscopic methods and single-crystal X-ray diffraction. Compound 1 possesses an unusual cyclopropane ring constructed through a hitherto unknown C-6/C-12 bond. Compound 2 represents the first 7,8-seco-ycopodane-derived alkaloid with a rare cyclobutane ring formed by a new C-12/C-15 linkage, while the C-8/C-15 bond remains. Compound 3 contains an unprecedented 12-spiro-9,12-gamma-lactone moiety. Their plausible biosynthetic pathways and antiaggregation effects on amyloid-beta(1-42) are also presented.
资助项目	NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700]
WOS关键词	ALKALOIDS ; AGGREGATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000382711200058
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275901]
专题	药理学第二研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Hai-Yan; Hu, Jin-Feng
作者单位	1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tang, Yu,Xiong, Juan,Zhang, Jing-Jing,et al. Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum[J]. ORGANIC LETTERS,2016,18(17):4376-4379.
APA	Tang, Yu,Xiong, Juan,Zhang, Jing-Jing,Wang, Wei,Zhang, Hai-Yan,&Hu, Jin-Feng.(2016).Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum.ORGANIC LETTERS,18(17),4376-4379.
MLA	Tang, Yu,et al."Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum".ORGANIC LETTERS 18.17(2016):4376-4379.