Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer

doi:10.1016/j.biomaterials.2016.06.005

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	Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer
	Tang, Shan; Meng, Qingshuo; Sun, Huiping; Su, Jinghan; Yin, Qi; Zhang, Zhiwen; Yu, Haijun; Chen, Lingli; Gu, Wangwen; Li, Yaping
刊名	BIOMATERIALS
	2017-01
卷号	114 页码:44-53
关键词	Breast cancer Charge-switch Metastasis Micelle pH-sensitive
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2016.06.005
文献子类	Article
英文摘要	For successful chemotherapy against metastatic breast cancer, the great efforts are still required for designing drug delivery systems that can be selectively internalized by tumor cells and release the cargo in a controlled manner. In this work, the chemotherapeutic agent paclitaxel (PTX) was loaded with the dual-pH sensitive micelle (DPM), which consisted of a pH-sensitive core, an acid-cleavable anionic shell, and a polyethylene glycol (PEG) corona. In the slightly acidic environment of tumor tissues, the anionic shell was taken off, inducing the conversion of the surface charge of DPM from negative to positive, which resulted in more efficient cellular uptake, stronger cytotoxicity and higher intra-tumor accumulation of PTX in the murine breast cancer 4T1 tumor-bearing mice models compared to the micelles with irremovable anionic or non-ionic shell. Meanwhile, the pH-sensitive core endowed DPM with rapid drug release in endo/lysosomes. The inhibitory rates of DPM against tumor growth and lung metastasis achieved 77.7% and 88.3%, respectively, without significant toxicity. Therefore, DPM is a promising nanocarrier for effective therapy of metastatic breast cancer due to satisfying the requirements of both selective uptake by tumor cells and sufficient and fast intracellular drug release. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81230029] ; National Natural Science Foundation of China[81302712] ; Youth Innovation Promotion Association of CAS[2015226]
WOS关键词	AMINO ESTER NANOPARTICLES ; HEPATOCELLULAR-CARCINOMA ; POLYMERIC NANOPARTICLES ; TARGETED DELIVERY ; CO-DELIVERY ; CELLS ; SURFACE ; DOXORUBICIN ; TUMOR ; SIRNA
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000389730000005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275754]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yin, Qi; Li, Yaping
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tang, Shan,Meng, Qingshuo,Sun, Huiping,et al. Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer[J]. BIOMATERIALS,2017,114:44-53.
APA	Tang, Shan.,Meng, Qingshuo.,Sun, Huiping.,Su, Jinghan.,Yin, Qi.,...&Li, Yaping.(2017).Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer.BIOMATERIALS,114,44-53.
MLA	Tang, Shan,et al."Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer".BIOMATERIALS 114(2017):44-53.