Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

doi:10.1002/adfm.201604300

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	Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer
	Sun, Huiping 1,2,3; Su, Jinghan 1,2,4; Meng, Qingshuo 1,2,4; Yin, Qi1,2 ; Chen, Lingli1,2 ; Gu, Wangwen1,2 ; Zhang, Zhiwen1,2 ; Yu, Haijun1,2 ; Zhang, Pengcheng1,2 ; Wang, Siling 3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2017-01
卷号	27 期号:3
ISSN号	1616-301X
DOI	10.1002/adfm.201604300
文献子类	Article
英文摘要	The cell-specific targeting drug delivery and controlled release of drug at the cancer cells are still the main challenges for anti-breast cancer metastasis therapy. Herein, the authors first report a biomimetic drug delivery system composed of doxorubicin (DOX)-loaded gold nanocages (AuNs) as the inner cores and 4T1 cancer cell membranes (CMVs) as the outer shells (coated surface of DOX-incorporated AuNs (CDAuNs)). The CDAuNs, perfectly utilizing the natural cancer cell membranes with the homotypic targeting and hyperthermia-responsive ability to cap the DAuNs with the photothermal property, can realize the selective targeting of the homotypic tumor cells, hyperthermia-triggered drug release under the near-infrared laser irradiation, and the combination of chemo/photothermal therapy. The CDAuNs exhibit a stimuli-release of DOX under the hyperthermia and a high cell-specific targeting of the 4T1 cells in vitro. Moreover, the excellent combinational therapy with about 98.9% and 98.5% inhibiting rates of the tumor volume and metastatic nodules is observed in the 4T1 orthotopic mammary tumor models. As a result, CDAuNs can be a promising nanodelivery system for the future therapy of breast cancer.
资助项目	National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; National Basic Research Program of China[2015CB932103] ; CAS Frontier Science Key Research Project[QYZDJ-SSW-SMC020]
WOS关键词	NEAR-INFRARED LIGHT ; POLYMERIC NANOPARTICLES ; COMBINATION THERAPY ; IN-VITRO ; DELIVERY ; DOXORUBICIN ; PLATFORM ; TUMORS ; NANOCARRIER ; PACLITAXEL
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000391926700009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275750]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Siling; Li, Yaping
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Sun, Huiping,Su, Jinghan,Meng, Qingshuo,et al. Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(3).
APA	Sun, Huiping.,Su, Jinghan.,Meng, Qingshuo.,Yin, Qi.,Chen, Lingli.,...&Li, Yaping.(2017).Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,27(3).
MLA	Sun, Huiping,et al."Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 27.3(2017).