Identification of a diverse synthetic abietane diterpenoid library for anticancer activity

doi:10.1016/j.bmcl.2016.12.032

	Identification of a diverse synthetic abietane diterpenoid library for anticancer activity
	Xu, Hongtao 1,2; Liu, Lili 1; Fan, Xiaoting 1,4; Zhang, Guanjun 3; Li, Yuanchao 2; Jiang, Biao 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2017-02-01
卷号	27 期号:3 页码:505-510
关键词	Abietic acid Triptophenolide Diverse Natural-product-like Anticancer
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2016.12.032
文献子类	Article
英文摘要	A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of NFSC, China[21502114] ; China Postdoctoral Science Foundation[2015M581677] ; Open Foundation of the State Key Laboratory of Drug Research, China[SIMM1601KF-05]
WOS关键词	BIOLOGICAL EVALUATION ; ANTIBACTERIAL DISCOVERY ; TRIPTOLIDE ANALOGS ; ACID-DERIVATIVES ; RING-DISTORTION ; DESIGN ; CELLS ; TRIPTONIDE ; COMPLEX ; DRUGS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000392900600025
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275656]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Jiang, Biao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Xu, Hongtao,Liu, Lili,Fan, Xiaoting,et al. Identification of a diverse synthetic abietane diterpenoid library for anticancer activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(3):505-510.
APA	Xu, Hongtao,Liu, Lili,Fan, Xiaoting,Zhang, Guanjun,Li, Yuanchao,&Jiang, Biao.(2017).Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(3),505-510.
MLA	Xu, Hongtao,et al."Identification of a diverse synthetic abietane diterpenoid library for anticancer activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.3(2017):505-510.