Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution

doi:10.3390/11120988

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution
	Zhang, Li ; Qiu, Beiying ; Li, Xin ; Wang, Xin; Li, Jingya; Zhang, Yongliang ; Liu, Jian ; Li, Jia; Shen, Jingkang
刊名	MOLECULES
	2006-12
卷号	11 期号:12 页码:988-999
关键词	microwave irradiation nucleophilic substitution 6-substituted quinoxalines JSP-1
ISSN号	1420-3049
DOI	10.3390/11120988
文献子类	Article
英文摘要	A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.
WOS关键词	RECEPTOR ANTAGONISTIC ACTIVITY ; DUAL-SPECIFICITY PHOSPHATASE ; BIOLOGICAL PROPERTIES ; ORGANIC-SYNTHESIS ; PHENYL GROUP ; DERIVATIVES ; CHEMISTRY ; ACID ; JNK ; 5-AMINOMETHYLQUINOXALINE-2,3-DIONES
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL
WOS记录号	WOS:000243402400006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273438]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室
通讯作者	Shen, Jingkang
作者单位	1.Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Li,Qiu, Beiying,Li, Xin,et al. Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution[J]. MOLECULES,2006,11(12):988-999.
APA	Zhang, Li.,Qiu, Beiying.,Li, Xin.,Wang, Xin.,Li, Jingya.,...&Shen, Jingkang.(2006).Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.MOLECULES,11(12),988-999.
MLA	Zhang, Li,et al."Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution".MOLECULES 11.12(2006):988-999.