Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer

doi:10.1002/adfm.201605679

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer
	Cao, Haiqiang 1,2; Zou, Lili 3; He, Bin 2; Zeng, Lijuan 2; Huang, Yongzhuo2 ; Yu, Haijun2 ; Zhang, Pengcheng2 ; Yin, Qi2 ; Zhang, Zhiwen2 ; Li, Yaping2
刊名	ADVANCED FUNCTIONAL MATERIALS
	2017-03-17
卷号	27 期号:11
ISSN号	1616-301X
DOI	10.1002/adfm.201605679
文献子类	Article
英文摘要	The synergistic combination of photothermal and RNA interference therapy demonstrates great potential for effective treatment of metastatic breast cancer, but their efficacy is limited by the poor delivery efficiency to tumor. Herein, it is reported that an albumin biomimetic nanocorona (DRI-S@HSA) can accomplish the high accumulation and deep penetration within tumor tissues, thereby holding great promise for synergistic therapy. DRI-S@HSA is prepared by camouflaging human serum albumin (HSA) onto an IR-780 and small interfering RNA-loaded cell-penetrating peptide nanoassembly (DRI-S). In metastatic 4T1 breast cancer cells, DRI-S@HSA can be largely internalized, and cause significant inhibition on cell migration and proliferation in combination with laser irradiation. Surprisingly, in vivo, the albumin camouflage in DRI-S@HSA produces a 2.5-fold enhancement on tumor accumulation compared to the undecorated DRI-S, and dramatically improves the deep penetration capacity in tumor mass. Moreover, a single DRI-S@HSA treatment plus 808 nm laser irradiation results in an 83.6% inhibition on tumor growth and efficient prevention of lung metastases. Taken together, the findings can provide an encouraging biomimetic tumor-targeted drug delivery strategy to inhibit tumor progression and prevent lung metastases of breast cancer.
资助项目	National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2014CB931900] ; National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Institutes for Drug Discovery and Development of CAS[CASIMM0120163005] ; Youth Innovation Promotion Association of CAS[00000000] ; K.C. Wong Education Foundation[00000000]
WOS关键词	HUMAN SERUM-ALBUMIN ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; SIRNA DELIVERY ; PROTEIN CORONA ; CONTROLLED-RELEASE ; LUNG METASTASIS ; INHIBIT GROWTH ; GENE DELIVERY ; SOLID TUMORS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000397348100013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272739]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Medica, State key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Cao, Haiqiang,Zou, Lili,He, Bin,et al. Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(11).
APA	Cao, Haiqiang.,Zou, Lili.,He, Bin.,Zeng, Lijuan.,Huang, Yongzhuo.,...&Li, Yaping.(2017).Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,27(11).
MLA	Cao, Haiqiang,et al."Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 27.11(2017).