Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles

doi:10.1038/aps.2017.36

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	Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles
	Zhong, Tao 1; He, Bin 2,3; Cao, Hai-qiang 2,3; Tan, Tao 2,3; Hu, Hai-yan 2,3; Li, Ya-ping2,3 ; Zhang, Zhi-wen2,3
刊名	ACTA PHARMACOLOGICA SINICA
	2017-06
卷号	38 期号:6 页码:924-930
关键词	micelles cabazitaxel cancer metastasis breast cancer 4T1 breast cancer cells
ISSN号	1671-4083
DOI	10.1038/aps.2017.36
文献子类	Article
英文摘要	Cancer metastasis is the primary cause of high mortality in breast cancer patients. In this study, we loaded an anti-cancer drug, cabazitaxel (CTX), into polymeric micelles (CTX-loaded polymeric micelles, PCMs), and explored their therapeutic efficacy in breast cancer metastasis. The characteristics of PCMs were investigated, and their anti-metastatic efficacy was assessed using in vitro and in vivo evaluations. PCMs had an average diameter of 50.13 +/- 11.96 nm with a CTX encapsulation efficiency of 97.02%+/- 0.97%. PCMs could be effectively internalized into metastatic 4T1 breast cancer cells in vitro. CTX (10 ng/mL) or an equivalent concentration in PCMs did not significantly affected the viability of 4T1 cells, but dramatically decreased the cell migration activities. In an orthotopic metastatic breast cancer model, intravenously administered PCMs could be efficiently delivered to the tumor sites, resulting in a 71.6% inhibition of tumor growth and a 93.5% reduction of lung metastases. Taken together, our results verify the anti-metastatic efficacy of PCMs, thus providing an encouraging strategy for treating breast cancer metastasis.
资助项目	National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81521005] ; Institutes for Drug Discovery and Development of CAS[CASIMM0120163005] ; Youth Innovation Promotion Association of CAS[00000000]
WOS关键词	RESISTANT PROSTATE-CANCER ; TUMOR BLOOD-VESSELS ; LUNG METASTASIS ; DRUG-RESISTANCE ; THERAPEUTIC-EFFICACY ; MULTIDRUG-RESISTANCE ; IN-VITRO ; NANOPARTICLES ; DELIVERY ; CELLS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5998012
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000402526900017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272647]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhi-wen
作者单位	1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Tao,He, Bin,Cao, Hai-qiang,et al. Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles[J]. ACTA PHARMACOLOGICA SINICA,2017,38(6):924-930.
APA	Zhong, Tao.,He, Bin.,Cao, Hai-qiang.,Tan, Tao.,Hu, Hai-yan.,...&Zhang, Zhi-wen.(2017).Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles.ACTA PHARMACOLOGICA SINICA,38(6),924-930.
MLA	Zhong, Tao,et al."Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles".ACTA PHARMACOLOGICA SINICA 38.6(2017):924-930.