Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer

doi:10.1002/adfm.201701093

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	Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer
	Lang, Tianqun 1,2,3; Dong, Xinyue 1,2,4; Huang, Yan 1,2; Ran, Wei 1,2,3; Yin, Qi1,2 ; Zhang, Pengcheng1,2 ; Zhang, Zhiwen1,2 ; Yu, Haijun1,2 ; Li, Yaping1,2
刊名	ADVANCED FUNCTIONAL MATERIALS
	2017-07-12
卷号	27 期号:26
关键词	breast cancer cancer therapy metastasis monocytes tumor targeting
ISSN号	1616-301X
DOI	10.1002/adfm.201701093
文献子类	Article
英文摘要	Many immune cells are capable of homing to sites of disease and eradicating infections and abnormal cells. However, their efficacy is usually down-regulated in tumor microenvironments and it is difficult to boost. It is presumed that the anticancer activity of immune cells can be improved by integrating an additional therapeutic modality such as chemotherapy into the cells. Here, Ly6C(hi) monocytes armed with the paclitaxel (PTX)-loading pH-sensitive micelle (PM), termed as PM@MC, are prepared. The PM internalization does not significantly affect the properties of the host Ly6C(hi) monocytes. In the 4T1 metastatic breast cancer mice model, PM@MCs home to both primary tumor and the lung metastasis foci. PM@MC exhibit 15-fold higher intratumor PTX accumulation than the commercial PTX injection, and achieve a tumor inhibiting rate of 96.8% and a lung metastasis suppression rate of 99.2%. No significant change is recorded in histology of major organs and in hematological and biochemical parameters after PM@MC treatment. The pH-sensitive micelle/ Ly6C(hi) monocyte drug delivery device thus has the application potential in the targeting therapy of breast cancer with metastasis.
资助项目	National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81521005] ; Key scientific research program of CAS[QYZDJ-SSW-SMC020] ; Youth Innovation Promotion Association of CAS[2015226]
WOS关键词	DIFFERENT TUMOR MICROENVIRONMENTS ; ANTICANCER DRUG-DELIVERY ; CARBON NANOTUBES ; NANOPARTICLES ; MEMBRANE ; BIOMATERIALS ; CHEMOTHERAPY ; GROWTH ; LUNG ; IMMUNOSURVEILLANCE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000405105500010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272567]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yin, Qi; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Sch Pharmaceut Sci, Beijing 100049, Peoples R China; 4.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China
推荐引用方式 GB/T 7714	Lang, Tianqun,Dong, Xinyue,Huang, Yan,et al. Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(26).
APA	Lang, Tianqun.,Dong, Xinyue.,Huang, Yan.,Ran, Wei.,Yin, Qi.,...&Li, Yaping.(2017).Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,27(26).
MLA	Lang, Tianqun,et al."Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 27.26(2017).