Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy

doi:10.1021/acs.nanolett.7b02330

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	Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy
	He, Xinyu 1,2,3; Cao, Haiqiang 1,2,3; Wang, Hong 1,2,3; Tan, Tao 1,2; Yu, Haijun1,2 ; Zhang, Pengcheng1,2 ; Yin, Qi1,2 ; Zhang, Zhiwen1,2 ; Li, Yaping1,2
刊名	NANO LETTERS
	2017-09
卷号	17 期号:9 页码:5546-5554
关键词	Monocyte bioinspired nanoparticles protease cancer metastasis
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.7b02330
文献子类	Article
英文摘要	Metastasis causes high mortality of breast cancer, and the inability of drug delivery to metastatic sites remains a crucial challenge for antimetastasis therapy. Herein, we report that inflammatory monocytes loading legumain-activated nanoparticles can actively target lung metastases and initiate metastasis-specific intelligent drug release for antimetastasis therapy. The cytotoxic mertansine is conjugated to poly(styrene-co-maleic anhydride) with a legumain-sensitive peptide and self-assembled into nanoparticles (SMNs), and then loaded into inflammatory monocytes to prepare the SMNs-loaded monocytes delivery system (M-SMNs). M-SMNs would be in living state in circulation to ensure their active targeting to lung metastases, and responsively damaged at the metastatic sites upon the differentiation of monocytes into macrophages. The anticancer drugs are intelligently released from M-SMNs as free drug molecules and drug-loaded microvesicles, resulting in considerable inhibition on the proliferation, migration, and invasion activities of metastatic 4T1 breast cancer cells. Moreover, M-SMNs significantly improve the delivery to lung metastases and penetrate the metastatic tumors, thus producing a 77.8% inhibition of lung metastases. Taken together, our findings provide an intelligent biomimetic drug delivery strategy via the biological properties of inflammatory monocytes for effective antimetastasis therapy.
资助项目	National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; Youth Innovation Promotion Association of CAS[00000000]
WOS关键词	MESENCHYMAL STEM-CELLS ; TUMOR-ASSOCIATED MACROPHAGES ; BREAST-CANCER METASTASIS ; IN-VIVO ; DELIVERY ; NANOMEDICINE ; MEMBRANE ; NANOGHOSTS ; STRATEGIES ; MICELLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000411043500054
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272498]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Xinyu,Cao, Haiqiang,Wang, Hong,et al. Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy[J]. NANO LETTERS,2017,17(9):5546-5554.
APA	He, Xinyu.,Cao, Haiqiang.,Wang, Hong.,Tan, Tao.,Yu, Haijun.,...&Li, Yaping.(2017).Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy.NANO LETTERS,17(9),5546-5554.
MLA	He, Xinyu,et al."Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy".NANO LETTERS 17.9(2017):5546-5554.