Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts

doi:10.1002/asia.201701132

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 新药研究国家重点实验室

	Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts
	Wang, Dong-Yu 1,2,3,4,5; Morimoto, Koki 2; Yang, Ze-Kun 2,3,4; Wang, Chao 2,3,4; Uchiyama, Masanobu 2,3,4
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2017-10-05
卷号	12 期号:19 页码:2554-2557
关键词	chemoselectivity C-N bond cleavage cross-coupling organozinc single electron transfer
ISSN号	1861-4728
DOI	10.1002/asia.201701132
文献子类	Article
英文摘要	We report a direct cross-coupling reaction between diarylzinc (Ar2Zn) and aryltrimethylammonium salts (ArNMe3+center dot-OTf) in the presence of LiCl, via C-N bond cleavage. The reaction takes place smoothly upon heating in THF without any external catalyst, enabling an efficient and chemoselective formation of biaryl products. Mechanistic studies indicate that the reaction proceeds through a single electron transfer route.
资助项目	JSPS[17H05430] ; JSPS KAKENHI[17H06173] ; Asahi Glass Foundation[00000000] ; Nagase Science Technology Development Foundation[00000000] ; Sumitomo Foundation[00000000] ; Kobayashi International Scholarship Foundation[00000000] ; YakuGaku ShinKoKai Foundation[00000000]
WOS关键词	SINGLE-ELECTRON-TRANSFER ; CROSS-COUPLING REACTIONS ; ARYL GRIGNARD-REAGENTS ; ARYLTRIMETHYLAMMONIUM IODIDES ; NICKEL-COMPLEXES ; ALKENYL HALIDES ; ZINC REAGENTS ; BORYLATION ; ARYLSTANNANES ; ACTIVATION
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000412325700011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272456]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Wang, Chao; Uchiyama, Masanobu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo To 1130033, Japan; 3.RIKEN, Adv Elements Chem Res Team, RIKEN Ctr Sustainable Resource Sci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 4.RIKEN, Elements Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Dong-Yu,Morimoto, Koki,Yang, Ze-Kun,et al. Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts[J]. CHEMISTRY-AN ASIAN JOURNAL,2017,12(19):2554-2557.
APA	Wang, Dong-Yu,Morimoto, Koki,Yang, Ze-Kun,Wang, Chao,&Uchiyama, Masanobu.(2017).Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts.CHEMISTRY-AN ASIAN JOURNAL,12(19),2554-2557.
MLA	Wang, Dong-Yu,et al."Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts".CHEMISTRY-AN ASIAN JOURNAL 12.19(2017):2554-2557.