Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

doi:10.1039/c7cc07465d

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance
	Meng, Qingshuo 1,2,4; Meng, Jia 1,2,4; Ran, Wei 1,2,4; Su, Jinghan 1,2,4; Yang, Yuguang 3; Zhang, Pengcheng1,2,4 ; Li, Yaping1,2,4
刊名	CHEMICAL COMMUNICATIONS
	2017-11-28
卷号	53 期号:92 页码:12438-12441
ISSN号	1359-7345
DOI	10.1039/c7cc07465d
文献子类	Article
英文摘要	We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells.
资助项目	National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81671808] ; Youth Innovation Promotion Association of CAS[2017335]
WOS关键词	TRIGGERED DRUG-RELEASE ; SINGLET OXYGEN ; COMBINATION THERAPY ; RESISTANT TUMOR ; CANCER ; NANOPARTICLES ; LIPOSOMES ; CELL ; CONVERSION ; CISPLATIN
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000415661300013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272392]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Pengcheng; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 North Charles St, Baltimore, MD 21218 USA 4.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China;
推荐引用方式 GB/T 7714	Meng, Qingshuo,Meng, Jia,Ran, Wei,et al. Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance[J]. CHEMICAL COMMUNICATIONS,2017,53(92):12438-12441.
APA	Meng, Qingshuo.,Meng, Jia.,Ran, Wei.,Su, Jinghan.,Yang, Yuguang.,...&Li, Yaping.(2017).Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance.CHEMICAL COMMUNICATIONS,53(92),12438-12441.
MLA	Meng, Qingshuo,et al."Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance".CHEMICAL COMMUNICATIONS 53.92(2017):12438-12441.