Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis | |
Pu, De-Bing1,2,4; Wang, Ting3; Zhang, Xing-Jie2; Gao, Jun-Bo1,4; Zhang, Rui-Han2; Li, Xiao-Nian1; Wang, Yong-Mei1,4; Li, Xiao-Li2; Wang, He-Yao3![]() | |
刊名 | RSC ADVANCES
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2018 | |
卷号 | 8期号:12页码:6425-6435 |
ISSN号 | 2046-2069 |
DOI | 10.1039/c7ra13309j |
文献子类 | Article |
英文摘要 | Investigation of the leaves and stems of Premna szemaoensis resulted in the isolation of twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known abietane diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 -> 16)-abeo-abietane (7, 10-12, 14 and 15) and 17(15 -> 16), 18(4 -> 3)-diabeo-abietane (1-6, 13 and 16). The structures of the new compounds were established mainly by analyzing NMR and HRESIMS data. The absolute configurations of 1, 3 and 10 were confirmed by single crystal X-ray diffraction analysis. In bioactivity assays, compounds 11, 12, 14 and 15 were active against two human colon cancer cell lines (HCT-116 and HT-29) with IC50 values ranging from 8.8 to 34.3 mu M, and compounds 10, 13 and 14 exhibited effective free radical scavenging activity with IC50 values ranging from 35.6 to 41.5 mu M by DPPH experiment. |
资助项目 | NSFC[81422046] ; NSFC[21762048] ; NSFC[U1702286] ; State Key Laboratory of Drug Research[SIMM1705KF-05] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT_17R94] |
WOS关键词 | ALPHA-GLUCOSIDASE ; CLERODENDRUM-TRICHOTOMUM ; ICETEXANE DITERPENES ; LATIFOLIA ROXB ; ROOTS ; LEAVES ; ANTIOXIDANT ; CONSTITUENTS ; SUBSCANDENS ; INTEGRIFOLIA |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000425034000030 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/272333] ![]() |
专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Li, Xiao-Li; Wang, He-Yao; Xiao, Wei-Lie |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; 2.Yunnan Univ, Sch Chem Sci & Technol, State Key Lab Conservat & Utilizat Bioresources Y, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Pu, De-Bing,Wang, Ting,Zhang, Xing-Jie,et al. Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis[J]. RSC ADVANCES,2018,8(12):6425-6435. |
APA | Pu, De-Bing.,Wang, Ting.,Zhang, Xing-Jie.,Gao, Jun-Bo.,Zhang, Rui-Han.,...&Xiao, Wei-Lie.(2018).Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis.RSC ADVANCES,8(12),6425-6435. |
MLA | Pu, De-Bing,et al."Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis".RSC ADVANCES 8.12(2018):6425-6435. |
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