Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

doi:10.1007/s00018-012-1076-4

	Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response
	Hansen, Guido 3,4; Hilgenfeld, Rolf 1,2,3,4
刊名	CELLULAR AND MOLECULAR LIFE SCIENCES
	2013-03
卷号	70 期号:5 页码:761-775
关键词	X-ray crystallography Protein quality control Oligomerization PDZ domain Molecular switch
ISSN号	1420-682X
DOI	10.1007/s00018-012-1076-4
文献子类	Review
英文摘要	Protein quality control is vital for all living cells and sophisticated molecular mechanisms have evolved to prevent the excessive accumulation of unfolded proteins. High-temperature requirement A (HtrA) proteases have been identified as important ATP-independent quality-control factors in most species. HtrA proteins harbor a serine-protease domain and at least one peptide-binding PDZ domain to ensure efficient removal of misfolded or damaged proteins. One distinctive property of HtrAs is their ability to assemble into complex oligomers. Whereas all examined HtrAs are capable of forming pyramidal 3-mers, higher-order complexes consisting of up to 24 molecules have been reported. Tight control of chaperone and protease function is of pivotal importance in preventing deleterious HtrA-protease activity. In recent years, structural biology provided detailed insights into the molecular basis of the regulatory mechanisms, which include unique intramolecular allosteric signaling cascades and the dynamic switching of oligomeric states of HtrA proteins. Based on these results, functional models for many family members have been developed. The HtrA protein family represents a remarkable example of how structural and functional diversity is attained from the assembly of simple molecular building blocks.
资助项目	Chinese Academy of Sciences[2010T1S6] ; DFG Cluster of Excellence "Inflammation at Interfaces"[EXC 306] ; Fonds der Chemischen Industrie[00000000]
WOS关键词	HEAT-SHOCK-PROTEIN ; ENTERICA SEROVAR TYPHIMURIUM ; SERINE-PROTEASE ; ESCHERICHIA-COLI ; CRYSTAL-STRUCTURE ; PDZ DOMAIN ; MYCOBACTERIUM-TUBERCULOSIS ; PROTEOLYTIC ACTIVITY ; STRUCTURAL BASIS ; LISTERIA-MONOCYTOGENES
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	SPRINGER BASEL AG
WOS记录号	WOS:000314716100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277716]
专题	中国科学院上海药物研究所
通讯作者	Hansen, Guido
作者单位	1.DESY, Lab Struct Biol Infect & Inflammat, D-22603 Hamburg, Germany 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Med Univ Lubeck, Inst Biochem, Ctr Struct & Cell Biol Med, D-23538 Lubeck, Germany; 4.Med Univ Lubeck, German Ctr Infect Res DZIF, D-23538 Lubeck, Germany;
推荐引用方式 GB/T 7714	Hansen, Guido,Hilgenfeld, Rolf. Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2013,70(5):761-775.
APA	Hansen, Guido,&Hilgenfeld, Rolf.(2013).Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response.CELLULAR AND MOLECULAR LIFE SCIENCES,70(5),761-775.
MLA	Hansen, Guido,et al."Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response".CELLULAR AND MOLECULAR LIFE SCIENCES 70.5(2013):761-775.