SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo

doi:10.1016/j.cellsig.2015.02.027

	SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo
	Jian, Hong 1; Zhao, Yi 1; Liu, Bin 2; Lu, Shun 1
刊名	CELLULAR SIGNALLING
	2015-06
卷号	27 期号:6 页码:1208-1213
关键词	SEMA4B Non-small cell lung cancer (NSCLC) PI3K FoxO1 P21
ISSN号	0898-6568
DOI	10.1016/j.cellsig.2015.02.027
文献子类	Article
英文摘要	We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. In the current study, we evaluated whether SEMA4B may also affect the growth of NSCLC. We thus used two human NSCLC lines, A549 and Calu-3, to examine our hypothesis. We found that overexpression of SEMA4B significantly decreased NSCLC cell growth, while SEMA4B inhibition significantly increased NSCLC cell growth, both in vitro and in vivo in an implanted NSCLC model. Adaptation of SEMA4B in NSCLC cells did not alter cell apoptosis, but changed the cell proliferation. Further analyses show that SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. Our study thus demonstrate a role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. (C) 2015 Elsevier Inc. All rights reserved.
资助项目	Wujieping Medical Foundation[320.6750.14060] ; Shanghai Chest Hospital Science and Technology Development Fund[2014 YZDC10600]
WOS关键词	FOXO1 NUCLEAR EXCLUSION ; TRANSCRIPTION FACTOR ; PROLIFERATION ; PHOSPHORYLATION ; METASTASIS ; AUTOPHAGY ; INACTIVATION ; ACTIVATION ; EXPRESSION ; MIGRATION
WOS研究方向	Cell Biology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000353096700017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276516]
专题	中国科学院上海药物研究所
通讯作者	Lu, Shun
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Shanghai 200030, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Jian, Hong,Zhao, Yi,Liu, Bin,et al. SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo[J]. CELLULAR SIGNALLING,2015,27(6):1208-1213.
APA	Jian, Hong,Zhao, Yi,Liu, Bin,&Lu, Shun.(2015).SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo.CELLULAR SIGNALLING,27(6),1208-1213.
MLA	Jian, Hong,et al."SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo".CELLULAR SIGNALLING 27.6(2015):1208-1213.