Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions

doi:10.1016/j.jchromb.2015.11.024

	Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions
	Wu, Xu 1,2,3; Ma, Jiang 1,2,3; Ye, Yang1,3,4 ; Lin, Ge 1,2,3
刊名	JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
	2016-07-15
卷号	1026 页码:236-253
关键词	Herb-drug interaction Solute carrier transporter ATP-binding cassette transporter Chinese herbal medicines Natural products
ISSN号	1570-0232
DOI	10.1016/j.jchromb.2015.11.024
文献子类	Article
英文摘要	The increasing use of Chinese herbal medicines (CHMs) as complementary therapy and dietary supplement has been greatly raising the concerns about potential herb-drug interactions (HDIs). HDIs may cause the augmented or antagonized effects of prescription drugs, resulting in unexpected clinical outcomes. Therefore, it is of significance to identify or predict potential HDIs, and to delineate the underlying mechanisms. Drug transporters play key roles in transmembrane passage of a large number of drugs, affecting their absorption, distribution and elimination. Modulation of drug transporters has been recognized as one of the main causes of HDIs. In the last decade, a growing number of Chinese medicinal herbs and their derived phytochemicals have been identified to have modulatory effect toward transporter proteins, leading to pharmacokinetic HDIs when concomitantly used with conventional drugs. Some of these transporter-mediated interactions have already shown clinical significance. This review article focuses on two major transporter superfamilies, the solute carrier (SLC) and the ATP-binding cassette (ABC) transporters, to provide the recent advanced knowledge on CHMs and their inherent phytochemicals that interact with these transporters, and their induced pharmacokinetic HDIs from both preclinical and clinical aspects. In addition, the challenges and strategy for studying HDIs are also discussed. (C) 2015 Elsevier B.V. All rights reserved.
资助项目	CUHK School of Biomedical Sciences-Seed Fund for Joint Establishments[00000000]
WOS关键词	SCHISANDRA-SPHENANTHERA-EXTRACT ; P-GLYCOPROTEIN EXPRESSION ; GINKGO-BILOBA EXTRACT ; PREGNANE X RECEPTOR ; BLOOD-BRAIN-BARRIER ; SALVIA-MILTIORRHIZA BUNGE ; RESISTANCE-ASSOCIATED PROTEIN-1 ; SOLUTE CARRIER TRANSPORTERS ; MAJOR ACTIVE CONSTITUENT ; BREAST-CANCER CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000379636800026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275957]
专题	中国科学院上海药物研究所
通讯作者	Lin, Ge
作者单位	1.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 2.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Hong Kong, Hong Kong, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xu,Ma, Jiang,Ye, Yang,et al. Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2016,1026:236-253.
APA	Wu, Xu,Ma, Jiang,Ye, Yang,&Lin, Ge.(2016).Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1026,236-253.
MLA	Wu, Xu,et al."Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1026(2016):236-253.