Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions

doi:10.3390/catal6110169

	Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions
	Yu, Yang 2,3; Mang, Zhiguo 2,3; Yang, Wei 1; Li, Hao 2,3; Wang, Wei 2,3,4
刊名	CATALYSTS
	2016-11
卷号	6 期号:11
关键词	Pd(TFA)(2) [4+1] annulation alpha-alkenyl-dicarbonyl compounds unprotected primary amines one-pot tandem reaction regio-selective
ISSN号	2073-4344
DOI	10.3390/catal6110169
文献子类	Article
英文摘要	The Pd(TFA)(2)-catalyzed [4+1] annulation of chained or cyclic alpha-alkenyl-dicarbonyl compounds and unprotected primary amines for "one-pot" synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O-2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl) methane products.
资助项目	National Science Foundation of China[21372073] ; National Science Foundation of China[21572054] ; National Science Foundation of China[21572055] ; Fundamental Research Funds for the Central Universities[00000000] ; China 111 Project[B07023]
WOS关键词	N BOND FORMATION ; WACKER-TYPE CYCLIZATION ; C-H AMIDATION ; ATORVASTATIN CALCIUM ; SUBSTITUTED PYRROLES ; OXIDATIVE AMINATION ; EFFICIENT SYNTHESIS ; 3+2 CYCLOADDITION ; DERIVATIVES ; ALKENES
WOS研究方向	Chemistry
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000388371400004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275830]
专题	中国科学院上海药物研究所
通讯作者	Li, Hao; Wang, Wei
作者单位	1.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China; 3.East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China; 4.Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
推荐引用方式 GB/T 7714	Yu, Yang,Mang, Zhiguo,Yang, Wei,et al. Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions[J]. CATALYSTS,2016,6(11).
APA	Yu, Yang,Mang, Zhiguo,Yang, Wei,Li, Hao,&Wang, Wei.(2016).Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions.CATALYSTS,6(11).
MLA	Yu, Yang,et al."Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions".CATALYSTS 6.11(2016).