Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis

doi:10.1002/hep.28887

	Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis
	Hu, Hongli 2; Zhu, Wenwei 3,4,5; Qin, Jun 6,7; Chen, Min 2; Gong, Liyan 2; Li, Long 2; Liu, Xiangyuan 2; Tao, Yongzhen 8; Yin, Huiyong 8; Zhou, Hu
刊名	HEPATOLOGY
	2017-02
卷号	65 期号:2 页码:515-528
ISSN号	0270-9139
DOI	10.1002/hep.28887
文献子类	Article
英文摘要	Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and liver cancer patient survival. Furthermore, depletion of PGK1 dramatically reduced cancer cell proliferation and tumorigenesis, indicating an oncogenic role of PGK1 in liver cancer progression. Moreover, we identified acetylation at the K323 site of PGK1 as an important regulatory mechanism for promoting its enzymatic activity and cancer cell metabolism. And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells. Conclusion: These findings demonstrate a novel regulation of PGK1 as well as its important role in liver cancer progression.
资助项目	Ministry of Science and Technology of China[2015CB964502] ; National Natural Science foundation of China[81372602] ; National Natural Science foundation of China[81422033]
WOS关键词	PHOSPHOGLYCERATE KINASE ; HEPATOCELLULAR-CARCINOMA ; PYRUVATE-KINASE ; TUMOR-GROWTH ; METABOLISM ; EXPRESSION ; TRANSCRIPTION ; GLYCOLYSIS ; MUTATIONS ; ISOFORM
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	WILEY
WOS记录号	WOS:000397300700014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275644]
专题	中国科学院上海药物研究所
通讯作者	Gao, Daming
作者单位	1.Fudan Univ, Coll Life Sci, Shanghai Med Coll, Key Lab Mol Med Minist Educ, Shanghai, Peoples R China; 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Innovat Ctr Cell Signaling Network, CAS Key Lab Syst Biol,Shanghai Inst Biol Sci,Inst, Shanghai, Peoples R China; 3.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China; 4.Fudan Univ, Inst Biomed Sci, Liver Canc Inst, Shanghai, Peoples R China; 5.Fudan Univ, Zhongshan Hosp, Inst Biomed Sci, Shanghai, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; 7.Shanghai Jiao Tong Univ Sch Med, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutrit Sci, Key Lab Food Safety Res, Shanghai, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 10.Fudan Univ, Coll Life Sci, Shanghai Med Coll, Inst Biomed Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Hu, Hongli,Zhu, Wenwei,Qin, Jun,et al. Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis[J]. HEPATOLOGY,2017,65(2):515-528.
APA	Hu, Hongli.,Zhu, Wenwei.,Qin, Jun.,Chen, Min.,Gong, Liyan.,...&Gao, Daming.(2017).Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis.HEPATOLOGY,65(2),515-528.
MLA	Hu, Hongli,et al."Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis".HEPATOLOGY 65.2(2017):515-528.