SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS

	SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS
	XU, J; LIANG, YY; ZHANG, JS; YAN, XM
刊名	ACTA PHARMACOLOGICA SINICA
	1991-09
卷号	12 期号:5 页码:441-&
关键词	DIMERCAPTOSUCCINIC ACID NICKEL TISSUE DISTRIBUTION AUTORADIOGRAPHY GEL CHROMATOGRAPHY
ISSN号	0253-9756
文献子类	Article
英文摘要	In mice and rats given iv or im (NiCl2)-Ni-63 148-370 kBq, radioactivity was present in highest concentrations in kidney, lung, and liver. After given ig dimercaptosuccinic acid (DMSA) 1 g.kg-1, radioactivity decreased remarkably in kidney, lung, and blood. The excretion of Ni-63 via urine and feces within 24 h, respectively 13.0 +/- 2.4% and 0.6 +/- 0.4%, was similar to that in the control group in mice. But radioactivity increased markedly in bone. The Ni content of bone decreased on d 7. In rats given im (NiCl2)-Ni-63 370 kBq, two different nickel complex peaks appeared in the gel chromatograms of serum, kidney, and lung. DMSA reduced the contents of protein-bound Ni in serum, kidney, and lung. The results showed that DMSA detoxified the Ni by forming a low toxicity Ni-DMSA complex to redistribute in the body.
WOS关键词	PULMONARY TUMOR RESPONSE ; STRAIN-A MICE ; METALLIC COMPOUNDS ; CARCINOGENICITY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
CSCD记录号	CSCD:162153
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1991GE60900015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275192]
专题	中国科学院上海药物研究所
通讯作者	XU, J
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	XU, J,LIANG, YY,ZHANG, JS,et al. SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(5):441-&.
APA	XU, J,LIANG, YY,ZHANG, JS,&YAN, XM.(1991).SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS.ACTA PHARMACOLOGICA SINICA,12(5),441-&.
MLA	XU, J,et al."SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS".ACTA PHARMACOLOGICA SINICA 12.5(1991):441-&.