EFFECTS OF DIMERCAPTOSUCCINIC ACID PER-OS ON COPPER EXCRETION IN RAT

	EFFECTS OF DIMERCAPTOSUCCINIC ACID PER-OS ON COPPER EXCRETION IN RAT
	YAN, XM; LI, L; LIANG, YY; TAO, ZQ; XU, XH; CHEN, ZJ; ZHANG, JS
刊名	ACTA PHARMACOLOGICA SINICA
	1993-11
卷号	14 页码:S34-S37
关键词	DIMERCAPTOSUCCINIC ACID COPPER ENTEROHEPATIC CIRCULATION ATOMIC ABSORPTION SPECTROPHOTOMETRY
ISSN号	0253-9756
文献子类	Article
英文摘要	After dimercaptosuccinic acid (DMSA) was given intragastrically by gavage (ig) 0, 250, or 500 mg . kg-1 following im CuSO4 30 mg . kg-1 daily X 3 d in rats, the Cu contents of serum increased markedly within 1-12 h. When ig DMSA daily X 3 d, the excretion of Cu in urine per 24 h in the treated group was greatly promoted vs the control (P < 0.01) , that in the 250 or 500 mg . kg-1 group were enhanced 2.4-3.8 and 5.8-7.8 times, respectively. That the excretion of Cu was increased in bile but not in feces suggested the plausible existence an enterohepatic circulation.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	日语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1993MH44400011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275120]
专题	中国科学院上海药物研究所
通讯作者	YAN, XM
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	YAN, XM,LI, L,LIANG, YY,et al. EFFECTS OF DIMERCAPTOSUCCINIC ACID PER-OS ON COPPER EXCRETION IN RAT[J]. ACTA PHARMACOLOGICA SINICA,1993,14:S34-S37.
APA	YAN, XM.,LI, L.,LIANG, YY.,TAO, ZQ.,XU, XH.,...&ZHANG, JS.(1993).EFFECTS OF DIMERCAPTOSUCCINIC ACID PER-OS ON COPPER EXCRETION IN RAT.ACTA PHARMACOLOGICA SINICA,14,S34-S37.
MLA	YAN, XM,et al."EFFECTS OF DIMERCAPTOSUCCINIC ACID PER-OS ON COPPER EXCRETION IN RAT".ACTA PHARMACOLOGICA SINICA 14(1993):S34-S37.