Synergism of sobuzoxane in combination with doxorubicin against leukemia P388 in mice

	Synergism of sobuzoxane in combination with doxorubicin against leukemia P388 in mice
	Dai, ZQ; Xu, JY; Yuan, XJ; Cai, JC
刊名	ACTA PHARMACOLOGICA SINICA
	1996-01
卷号	17 期号:1 页码:69-&
关键词	sobuzoxane doxorubicin leukemia P388 myocardium drug synergism electron microscopy
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the antitumor activity of sobuzoxane (Sob) in combination with doxorubicin (Dox) and the effect of Sob on Dox-induced cardiotoxicity. METHODS: DBA/2 mice bearing transplanted leukemia P388 were given iv Dox 2 mg . kg(-1). d(-1) for 3 d, 4 mg . kg(-1). d(-1) for 1 d combined with ig Sob 20, 40 mg . kg(-1). d(-1) for 7 d. The increase in life span (ILS) of each group was recorded in 30 d. The myocardium of moribund mice was examined by transmission electron microscopy. RESULTS: The ILS of combination therapeutic groups of Sob with Dox was 48.7%, 57.3%, 59.0%, and 62.4% respectively, which were 30%-90% higher than the sum of ILS of two groups treated with Dox and Sob separately (P < 0.01). The ultrastructural injury of cardiomyocytes of P388-bearing mice caused by combination chemotherapy with Dox plus Sob was markedly attenuated compared with Dox alone: CONCLUSION: Sob with Dox exhibited an antitumor synergistic effect on leukemia P388, and the cardiotoxicity of Dox was reduced by Sob.
WOS关键词	ACUTE DAUNORUBICIN TOXICITY ; SYRIAN GOLDEN-HAMSTERS ; BEAGLE DOGS ; BIS(2,6-DIOXOPIPERAZINE) ; ICRF-187 ; DERIVATIVES ; REDUCTION ; MST-16
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1996TQ30000019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275012]
专题	中国科学院上海药物研究所
通讯作者	Dai, ZQ
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Dai, ZQ,Xu, JY,Yuan, XJ,et al. Synergism of sobuzoxane in combination with doxorubicin against leukemia P388 in mice[J]. ACTA PHARMACOLOGICA SINICA,1996,17(1):69-&.
APA	Dai, ZQ,Xu, JY,Yuan, XJ,&Cai, JC.(1996).Synergism of sobuzoxane in combination with doxorubicin against leukemia P388 in mice.ACTA PHARMACOLOGICA SINICA,17(1),69-&.
MLA	Dai, ZQ,et al."Synergism of sobuzoxane in combination with doxorubicin against leukemia P388 in mice".ACTA PHARMACOLOGICA SINICA 17.1(1996):69-&.