Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin

	Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin
	Zhong, F ; Li, XY ; Yang, SL
刊名	ACTA PHARMACOLOGICA SINICA
	1996-03
卷号	17 期号:2 页码:182-185
关键词	methionine enkephalin tumor necrosis factor natural killer cells interleukin-12 gene expression
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the host immune surveillance functions by the neuropeptide methionine enkephalin (met-enk). METHODS: To measure the effects of met-enk on NK activity, the production and gene expression of anti-tumor cytokines tumor necrosis factor a (TNF-alpha) and interleukin-12 (IL-12) in vitro and In vivo. RESULT: Met-enk promoted NK activity at 1 x 10(-8) - 1 x 10(-5) mol . L(-1), increased TNF-alpha production both in vitro and in vivo, and enhanced IL-12 p35 gene transcription after ip 0.1 mg kg(-1) for 6 d. CONCLUSION: The upregulating effects of met-enk contribute to the host neuro-immunomodulating mechanism against tumors and invading antigens.
WOS关键词	PERIPHERAL-BLOOD LYMPHOCYTES ; MET-ENKEPHALIN
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:339723
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1996TZ76400024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274994]
专题	中国科学院上海药物研究所
作者单位	1.CHINESE ACAD SCI,SHANGHAI RES CTR BIOTECHNOL,SHANGHAI 200233,PEOPLES R CHINA 2.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	Zhong, F,Li, XY,Yang, SL. Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin[J]. ACTA PHARMACOLOGICA SINICA,1996,17(2):182-185.
APA	Zhong, F,Li, XY,&Yang, SL.(1996).Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin.ACTA PHARMACOLOGICA SINICA,17(2),182-185.
MLA	Zhong, F,et al."Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin".ACTA PHARMACOLOGICA SINICA 17.2(1996):182-185.