Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand

	Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand
	Kong, DY ; Xie, YL ; Xie, YY; Huang, XY
刊名	CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
	2000
卷号	19 期号:1 页码:39-47
关键词	synthesis macrocyclic ligand antitumor activity crystal structure
ISSN号	0254-5861
文献子类	Article
英文摘要	New tetraazamacrocyclic ligand with 1, 4, 7, 10-tetrakis (4-nitrobenzyl) pendent groups (C36H40N8O8, M-r = 712. 76) crystallized in the monoclinic system, P2(1)/n space group with unit cell parameters: a = 7. 834(2), b = 22. 902(6) , c = 10. 147(3)Angstrom, beta = 106. 53(2)degrees, V = 1715(1) Angstrom (3), Z = 2, D-c= 1. 356 g/cm(3) (,) lambda(Mo-k alpha) = 0. 71069 Angstrom; mu = 0. 92cm(-1), F(000) = 752, T = 296K. The final R and R-w values are 0. 065 and 0. 066, respectively. The Cu( I ), Nit ( I ), Co( I ), Zn( I ) complexes with this new ligand have been synthesized and characterized by elemental analyses, IR, UV, ESI-MS and molar conductance, The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with the general formula: M(L)(NO3)(2) . nH(2)O (M = Co, Ni, Cu, n = 2; M = Zn, n = 4; L = C36H40-N8O8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacological tests against P-388 and A-549 tumor cell lines showed that all these complexes had considerable activities in vitro.
WOS关键词	LANTHANIDE COMPLEXES ; MOLECULAR-STRUCTURE ; PHOSPHATE DIESTER ; EUROPIUM(III) ; LANTHANUM(III) ; ALCOHOL ; CRYSTAL ; RNA ; CONFORMATION ; CLEAVAGE
WOS研究方向	Chemistry ; Crystallography
语种	英语
CSCD记录号	CSCD:657754
出版者	CHINESE JOURNAL STRUCTURAL CHEMISTRY
WOS记录号	WOS:000084905500010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274658]
专题	中国科学院上海药物研究所
通讯作者	Kong, DY
作者单位	1.Rutgers State Univ, Dept Chem, Camden, NJ 08102 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Kong, DY,Xie, YL,Xie, YY,et al. Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2000,19(1):39-47.
APA	Kong, DY,Xie, YL,Xie, YY,&Huang, XY.(2000).Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,19(1),39-47.
MLA	Kong, DY,et al."Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 19.1(2000):39-47.