New tetraazamacrocyclic ligand with neutral pendent groups 1,4,7,10-tetrakis(2-cyanoethyl)-1,4,7,10-tetraazacyclododecane (L) and its cobalt(II), nickel(II) and copper(II) complexes: synthesis, structural characterization and antitumor activity

doi:10.1016/S0277-5387(99)00369-1

	New tetraazamacrocyclic ligand with neutral pendent groups 1,4,7,10-tetrakis(2-cyanoethyl)-1,4,7,10-tetraazacyclododecane (L) and its cobalt(II), nickel(II) and copper(II) complexes: synthesis, structural characterization and antitumor activity
	Kong, DY ; Meng, LH; Ding, J; Xie, YY; Huang, XY
刊名	POLYHEDRON
	2000-01-30
卷号	19 期号:2 页码:217-223
关键词	transition metals synthesis structural characterization antitumor activity
ISSN号	0277-5387
DOI	10.1016/S0277-5387(99)00369-1
文献子类	Article
英文摘要	A new tetraazamacrocyclic ligand (L) with four neutral 2-cyanoethyl pendent groups, and its divalent transition-metal complexes [Co(L) (NO3)]NO3 . H2O (1), [Ni(L) (NO3)]NO3 . 3H(2)O (2) and [Cu(L) (H2O)] (NO3)(2) (3) have been synthesized. The crystal structures of 1 and 3 have been determined by X-ray analysis. In complex 1 the cobalt atom is coordinated by four nitrogen atoms and two oxygen atoms of a nitrate anion, which define a distorted octahedron. The other nitrate ion lies in the lattice as a counter ion. Complex 3 is five-coordinated by four nitrogen atoms and an axial aqua ligand, which form a tetragonal pyramid. In complex 3 the two nitrate anions exist as counter ions. Pharmaceutical tests showed that all three metal complexes exhibit antitumor activity against HL-60 and BEL-7404 tumor cell lines in vitro, even at a concentration of 10(-8) mol l(-1). Complex 1 can partially cleave supercoiled pBR 322 DNA to form nicked DNA in aerobic solution, and complex 3 can convert double strand DNA into nicked DNA completely in the presence of MPA. Complex 3 causes perturbation to K562 tumor cell lines in the G(1) phase. (C) 2000 Elsevier Science Ltd All rights reserved.
WOS关键词	NUCLEAR MAGNETIC-RESONANCE ; ANTICANCER DRUG CISPLATIN ; METAL-COMPLEXES ; MACROCYCLIC POLYAMINES ; TETRAAZA MACROCYCLE ; MAJOR ADDUCT ; RING SIZE ; DNA ; LANTHANIDE(III) ; REPLICATION
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000086051100013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274648]
专题	中国科学院上海药物研究所
通讯作者	Kong, DY
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China 2.Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Kong, DY,Meng, LH,Ding, J,et al. New tetraazamacrocyclic ligand with neutral pendent groups 1,4,7,10-tetrakis(2-cyanoethyl)-1,4,7,10-tetraazacyclododecane (L) and its cobalt(II), nickel(II) and copper(II) complexes: synthesis, structural characterization and antitumor activity[J]. POLYHEDRON,2000,19(2):217-223.
APA	Kong, DY,Meng, LH,Ding, J,Xie, YY,&Huang, XY.(2000).New tetraazamacrocyclic ligand with neutral pendent groups 1,4,7,10-tetrakis(2-cyanoethyl)-1,4,7,10-tetraazacyclododecane (L) and its cobalt(II), nickel(II) and copper(II) complexes: synthesis, structural characterization and antitumor activity.POLYHEDRON,19(2),217-223.
MLA	Kong, DY,et al."New tetraazamacrocyclic ligand with neutral pendent groups 1,4,7,10-tetrakis(2-cyanoethyl)-1,4,7,10-tetraazacyclododecane (L) and its cobalt(II), nickel(II) and copper(II) complexes: synthesis, structural characterization and antitumor activity".POLYHEDRON 19.2(2000):217-223.