Molecular modeling of kappa opioid receptor-Gi protein recognition

	Molecular modeling of kappa opioid receptor-Gi protein recognition
	Wan, XH ; Huang, XQ ; Zhou, DH ; Jiang, HL; Feng, YP ; Chen, KX; Chi, ZQ
刊名	PROTEIN AND PEPTIDE LETTERS
	2000-12
卷号	7 期号:6 页码:403-409
ISSN号	0929-8665
文献子类	Article
英文摘要	This work theoretically studied the mechanism involved in recognition of Gi protein and kappa opioid receptor with shape matching method. We used the human kappa opioid receptor model docking with dynorphin A(1-8)(HKOR_DYN) to mimic the active form of HKOR. The modeling results suggested the cluster formed by A4, A5, AG and B6 in the alpha subunit of Gi protein (G alphai) might be the binding core with intercellular solvent face of HKOR and some residues of the intracellular loops play an important role in Gi protein coupling.
WOS关键词	ACTIVATION ; MECHANISM ; DOCKING
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000165246800008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274554]
专题	中国科学院上海药物研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wan, XH,Huang, XQ,Zhou, DH,et al. Molecular modeling of kappa opioid receptor-Gi protein recognition[J]. PROTEIN AND PEPTIDE LETTERS,2000,7(6):403-409.
APA	Wan, XH.,Huang, XQ.,Zhou, DH.,Jiang, HL.,Feng, YP.,...&Chi, ZQ.(2000).Molecular modeling of kappa opioid receptor-Gi protein recognition.PROTEIN AND PEPTIDE LETTERS,7(6),403-409.
MLA	Wan, XH,et al."Molecular modeling of kappa opioid receptor-Gi protein recognition".PROTEIN AND PEPTIDE LETTERS 7.6(2000):403-409.