Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

doi:10.1021/np0200257

	Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia
	Zhao, Y ; Hao, XJ ; Lu, W ; Cai, JC ; Yu, H ; Sevenet, T ; Gueritte, F
刊名	JOURNAL OF NATURAL PRODUCTS
	2002-06
卷号	65 期号:6 页码:902-908
ISSN号	0163-3864
DOI	10.1021/np0200257
文献子类	Article
英文摘要	Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000176688300018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274355]
专题	中国科学院上海药物研究所
通讯作者	Zhao, Y
作者单位	1.Inmore Lab Biotechnol, Kunming 650011, Peoples R China 2.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France 3.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Y,Hao, XJ,Lu, W,et al. Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(6):902-908.
APA	Zhao, Y.,Hao, XJ.,Lu, W.,Cai, JC.,Yu, H.,...&Gueritte, F.(2002).Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.JOURNAL OF NATURAL PRODUCTS,65(6),902-908.
MLA	Zhao, Y,et al."Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia".JOURNAL OF NATURAL PRODUCTS 65.6(2002):902-908.