beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese

doi:10.1081/CEH-200031839

	beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese
	Huang, G ; Xing, HX ; Hao, K ; Peng, SJ ; Wu, D ; Guang, WW ; Huang, AQ ; Hong, XM ; Wang, YP; Feng, Y
刊名	CLINICAL AND EXPERIMENTAL HYPERTENSION
	2004-08
卷号	26 期号:6 页码:581-592
关键词	ADRB2 gene gene polymorphism benazepril blood pressure pharmacogenetics
ISSN号	1064-1963
DOI	10.1081/CEH-200031839
文献子类	Article
英文摘要	Background: There is considerable variability in individual response to antihypertensive agents. The reason for this is not known, but may be related to individual genetic variability. This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta(2) adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism. Methods and Results: We conducted a family-based study of 321 and 610 hypertensive subjects from Yuexi and Huoqiu Counties of Anhui, China, respectively. Both systolic and diastolic blood pressures (SBP and DBP) before and after a 15-day benazepril treatment were measured. ADRB2 R16G genotypes were determined for all subjects. ADRB2 G16 allele frequency was found to be 41.0% and. 47.4% in Huoqiu and Yuexi, respectively. In Yuexi family-based association test (FBAT) revealed that the G16 allele was associated with a greater DBP decrease in response to a 15-day benazepril treatment (Z = 2.12, P = 0.03), and the data were consistent with a dominant inheritance model. A similar trend was observed in Huoqiu Chinese, but the magnitudes of effects were smaller and did not reach statistical significance. The FBAT results were further confirmed by using a generalized estimating equation model. Conclusion: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.
资助项目	NIEHS NIH HHS[ES00002]
WOS关键词	CONVERTING-ENZYME-INHIBITOR ; BETA-2-ADRENERGIC RECEPTOR ; BLOOD-PRESSURE ; UNIFIED APPROACH ; DRUG-THERAPY ; POPULATION ; VASODILATION ; HEALTH ; GENOME ; ASTHMA
WOS研究方向	Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000224975200012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274042]
专题	中国科学院上海药物研究所
通讯作者	Xu, XP
作者单位	1.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China 3.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China 4.Peking Univ, Sch Med, Dept Genet & Cell Biol, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China 5.Peking Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, Beijing 100871, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 7.Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA 8.Boston Med Ctr, Boston, MA USA 9.Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Prevent Med, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Huang, G,Xing, HX,Hao, K,et al. beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2004,26(6):581-592.
APA	Huang, G.,Xing, HX.,Hao, K.,Peng, SJ.,Wu, D.,...&Xu, XP.(2004).beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese.CLINICAL AND EXPERIMENTAL HYPERTENSION,26(6),581-592.
MLA	Huang, G,et al."beta(2) adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese".CLINICAL AND EXPERIMENTAL HYPERTENSION 26.6(2004):581-592.