Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials

doi:10.1016/j.actbio.2018.10.015

	Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials
	Tong, Xian 5,6; Zhang, Dechuang 5; Zhang, Xiaotuan 3,7; Su, Yingchao 1; Shi, Zimu 6; Wang, Kun 6; Lin, Jianguo 5; Li, Yuncang 4; Lin, Jixing 2,6; Wen, Cuie 4
刊名	Acta biomaterialia
	2018-12
卷号	82 页码:197-204
ISSN号	1878-7568
DOI	10.1016/j.actbio.2018.10.015
文献子类	Article
英文摘要	Zinc (Zn)-based alloys are considered a new class of biodegradable implant materials due to their superior chemical stability and processability compared to biodegradable magnesium (Mg) alloys. In this study, we report a new biodegradable Zn-5Ge alloy with highly desirable mechanical, corrosion, and biological properties. Microstructural characterization revealed the effective grain-refining effect of germanium (Ge) on the Zn alloy. Tensile test results indicated that the hot-rolled Zn-5Ge alloy showed an ultimate tensile strength of 237.0 MPa, a yield strength of 175.1 MPa, and an elongation of 21.6%; while as-cast pure Zn showed an ultimate tensile strength of 33.6 MPa, a yield strength of 29.3 MPa, and an elongation of 1.2%. The corrosion rates measured by potentiodynamic polarization tests in Hank's solution in ascending order are: as-cast Zn-5Ge (0.1272 mm/y) < as-cast pure Zn (0.1567 mm/y) < hot-rolled Zn-5Ge (0.2255 mm/y) < hot-rolled pure Zn (0.3057 mm/y). Immersion tests revealed that the degradation rate of as-cast Zn-5Ge is 0.042 mm/y, less than half of that of hot-rolled pure Zn and ∼62% of that of as-cast pure Zn. Moreover, the Zn-5Ge alloy showed excellent in vitro hemocompatibility and the addition of 5% Ge effectively enhanced the hemocompatibility of pure Zn. CCK-8 assay using murine preosteoblast MC3T3-E1 cells indicated that the diluted extracts at a concentration <12.5% of both the as-cast Zn-5Ge alloy and pure Zn showed grade 0 cytotoxicity; the diluted extracts at the concentrations of 50% and 25% of Zn-5Ge alloy showed a significantly higher cell viability than those of pure Zn. STATEMENT OF SIGNIFICANCE: Zinc (Zn)-based alloys are currently considered a new class of biodegradable implant materials due to their excellent processability. Here, we report a novel Zn-5Ge alloy with highly desirable mechanical, corrosion and biological properties. The tensile test results indicated that the hot-rolled Zn-5Ge alloy showed an ultimate tensile strength of 237.0 MPa, a yield strength of 175.1 MPa and an elongation of 21.6%; while as-cast pure Zn showed an ultimate tensile strength of 33.6 MPa, a yield strength of 29.3 MPa and an elongation of 1.2%. The corrosion rate measured by potentiodynamic polarization tests in Hank's solution in the ascending order is: as-cast Zn-5Ge (0.1272 mm/y) < as-cast pure Zn (0.1567 mm/y) < hot-rolled Zn-5Ge (0.2255 mm/y) < hot-rolled pure Zn (0.3057 mm/y). Immersion tests revealed that the degradation rate of the as-cast Zn-5Ge is 0.042 mm/y, less than half of that of the hot-rolled pure Zn, ∼62% of that of as-cast pure Zn. Moreover, the Zn-5Ge alloy showed excellent in vitro biocompatibility.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266575]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Dechuang; Lin, Jixing; Wen, Cuie
作者单位	1.Department of Biomedical Engineering, University of North Texas, Denton, TX 76203, USA; 2.School of Physics and Optoelectronics Xiangtan University, Xiangtan 411105, China 3.University of Chinese Academy of Sciences, Graduate School, 19A Yuquan Road, Beijing 100049, China; 4.School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia; 5.School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China; 6.Department of Material Engineering, Zhejiang Industry & Trade Vocational College, Wenzhou 325003, China; 7.National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
推荐引用方式 GB/T 7714	Tong, Xian,Zhang, Dechuang,Zhang, Xiaotuan,et al. Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials[J]. Acta biomaterialia,2018,82:197-204.
APA	Tong, Xian.,Zhang, Dechuang.,Zhang, Xiaotuan.,Su, Yingchao.,Shi, Zimu.,...&Wen, Cuie.(2018).Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials.Acta biomaterialia,82,197-204.
MLA	Tong, Xian,et al."Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials".Acta biomaterialia 82(2018):197-204.