Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L

doi:10.1002/bmc.4328

	Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L
	Chen, Zhiyong 2; Du, Xia 2; Yang, Yuanyuan 3; Cui, Xiaomin 2; Zhang, Zijia 1; Li, Ye 2
刊名	Biomedical chromatography : BMC
	2018-11
卷号	32 期号:11 页码:e4328
ISSN号	1099-0801
DOI	10.1002/bmc.4328
文献子类	Article
英文摘要	Morus alba L has long been used as fodder and as a traditional medicine. The different parts of M. alba (Cortex Mori, Ramulus Mori, Folium Mori and Fructus Mori) have different bioactivities; however, most current evidence is focused on anti-diabetic properties. In spite of their widespread use, few studies have compared the chemical composition and activity against α-glucosidase of the various medicinal parts of M. alba. In this study, we developed an HPLC method for simultaneous quality control and discrimination of Cortex Mori, Ramulus Mori, Folium Mori and Fructus Mori using 13 marker compounds. We found that quercetin, morin, kuwanon G, sanggenon C, morusin, mulberroside A and rutin were chemically distinct among the various medicinal parts of M. alba. A spectrum-effect relationship method was established to compare α-glucosidase inhibitory activity of various batches of samples to determine the activity of the primary active components against α-glucosidase. Taken together with molecular docking data, we found that prenylated flavonoids (morin, sanggenon C, kuwanon G and morusin), flavonols (kaempferol, quercetin, rutin and isoquercitrin) and alkaloids (1-deoxynojirimycin) were small molecule α-glucosidase inhibitory ingredients. In conclusion, we laid a solid foundation for effective substance identification in various parts of M. alba, and simultaneously provided a basis for their quality control.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266461]
专题	中国科学院上海药物研究所
作者单位	1.The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2.Shaanxi Academy of Traditional Chinese Medicine, Xi'an, Shaanxi, China; 3.Xi'an Institute for Food and Drug Control, Xi'an, Shaanxi, China;
推荐引用方式 GB/T 7714	Chen, Zhiyong,Du, Xia,Yang, Yuanyuan,et al. Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L[J]. Biomedical chromatography : BMC,2018,32(11):e4328.
APA	Chen, Zhiyong,Du, Xia,Yang, Yuanyuan,Cui, Xiaomin,Zhang, Zijia,&Li, Ye.(2018).Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L.Biomedical chromatography : BMC,32(11),e4328.
MLA	Chen, Zhiyong,et al."Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L".Biomedical chromatography : BMC 32.11(2018):e4328.