A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration

doi:10.1007/s13318-015-0254-9

	A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration
	Duan, Jingze 1; Dang, Yang 1; Meng, Houjun 1; Wang, Huizhen 1; Ma, Ping 2; Li, Guowen 3; Wu, Tao 3; Xie, Yan 1
刊名	European journal of drug metabolism and pharmacokinetics
	2016-06
卷号	41 期号:3 页码:239-49
ISSN号	2107-0180
DOI	10.1007/s13318-015-0254-9
文献子类	Article
英文摘要	Pharmacokinetic properties of isorhamnetin, quercetin, and kaempferol in three different total flavones of Hippophae rhamnoides (TFH) preparations were compared after oral administration to beagle dogs by a UPLC-MS method. The pharmacokinetic results showed that C max of isorhamnetin and quercetin in TFH solid dispersion (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly enhanced than that in TFH preparations (p < 0.05). The AUCs of isorhamnetin and quercetin in TFH-SD were 5.9- and 3.1-fold higher than that of TFH, while the AUCs of isorhamnetin and quercetin in TFH-SE were 3.4- and 2.4-fold higher than that of TFH. These findings suggested that the oral bioavailability of isorhamnetin and quercetin in beagle dogs can be significantly increased in TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to explore the new forms for oral administration TFH and explain their in vivo processes.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266431]
专题	中国科学院上海药物研究所
通讯作者	Xie, Yan
作者单位	1.Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China; 2.Global Pharmaceutical Research and Development, Hospira Inc., 1776 North Centennial Drive, Mcpherson, KS, 67460, USA; 3.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
推荐引用方式 GB/T 7714	Duan, Jingze,Dang, Yang,Meng, Houjun,et al. A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration[J]. European journal of drug metabolism and pharmacokinetics,2016,41(3):239-49.
APA	Duan, Jingze.,Dang, Yang.,Meng, Houjun.,Wang, Huizhen.,Ma, Ping.,...&Xie, Yan.(2016).A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration.European journal of drug metabolism and pharmacokinetics,41(3),239-49.
MLA	Duan, Jingze,et al."A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration".European journal of drug metabolism and pharmacokinetics 41.3(2016):239-49.