Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

doi:10.1080/14786419.2017.1320795

	Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity
	Liu, Xin 2; Yin, Chengle 2; Cao, Yue 2; Zhou, Jinge 1; Wu, Tao 1; Cheng, Zhihong 2
刊名	Natural product research
	2018-05
卷号	32 期号:10 页码:1145-1149
ISSN号	1478-6427
DOI	10.1080/14786419.2017.1320795
文献子类	Article
英文摘要	A new triterpenoid glycoside (1) and 15 known compounds (2-16) were isolated from the whole plants of Gueldenstaedtia verna. The new compound (1) was identified as complogenin 22-O-β-d-glucopyranoside by extensive spectroscopic techniques including 1D (H and C) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (13), on the production of pro-inflammatory mediators (including IL-6, IL1β and PGE) were further estimated in vitro by ELISA in RAW 264.7 macrophages.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266392]
专题	中国科学院上海药物研究所
作者单位	1.b Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica , Shanghai University of Traditional Chinese Medicine , Shanghai , China 2.a Department of Pharmacognosy , School of Pharmacy, Fudan University , Shanghai , China;
推荐引用方式 GB/T 7714	Liu, Xin,Yin, Chengle,Cao, Yue,et al. Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity[J]. Natural product research,2018,32(10):1145-1149.
APA	Liu, Xin,Yin, Chengle,Cao, Yue,Zhou, Jinge,Wu, Tao,&Cheng, Zhihong.(2018).Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity.Natural product research,32(10),1145-1149.
MLA	Liu, Xin,et al."Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity".Natural product research 32.10(2018):1145-1149.