γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis

doi:10.1016/j.taap.2018.11.011

	γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis
	Wang, Anqi 2,3; Zhou, Fayang 2; Li, Dan 2; Lu, Jin-Jian 2; Wang, Yitao 2; Lin, Ligen 1,2
刊名	Toxicology and applied pharmacology
	2019-01-15
卷号	363 页码:142-153
ISSN号	1096-0333
DOI	10.1016/j.taap.2018.11.011
文献子类	Article
英文摘要	The activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. In the current study, γ-mangostin (γ-man), one of the major xanthones from mangosteen (Garcinia mangostana), was found to alleviate fibrogenesis in human immortalized HSCs (LX-2 cells) and in liver from chronic carbon tetrachloride (CCl) injured mice. γ-Man suppressed the expression levels of collagen I and α-smooth muscle actin (α-SMA) in LX-2 cells in both dose and time dependent manners. Furthermore, γ-man inhibited NAD(P)H oxidase activity through induction of sirtuin 3 (SIRT3), resulting in reduced intracellular oxidative stress in LX-2 cells. Moreover, γ-man stimulated the expression of histone deacetylase 1, which in turn decreased the acetylation and cytoplasmic shuttling of high mobility group box 1 (HMGB1), to impair autocrine HMGB1-induced HSC activation. In CCl-injured mice, γ-man enhanced the expression of SIRT3 and decreased the expression of HMGB1, resulting in decreased accumulation of collagen I and α-SMA in liver. Consequently, γ-man might be a potent candidate to treat oxidative stress induced liver fibrosis.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266359]
专题	中国科学院上海药物研究所
通讯作者	Lin, Ligen
作者单位	1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau 999078, China; 3.Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, Guangdong 519031, China;
推荐引用方式 GB/T 7714	Wang, Anqi,Zhou, Fayang,Li, Dan,et al. γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis[J]. Toxicology and applied pharmacology,2019,363:142-153.
APA	Wang, Anqi,Zhou, Fayang,Li, Dan,Lu, Jin-Jian,Wang, Yitao,&Lin, Ligen.(2019).γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.Toxicology and applied pharmacology,363,142-153.
MLA	Wang, Anqi,et al."γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis".Toxicology and applied pharmacology 363(2019):142-153.