A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment

doi:10.1111/biom.13029

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	A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment
	Zhang, Wei 1; Liu, Aiyi 1; Tang, Larry L.2,3; Li, Qizhai4
刊名	BIOMETRICS
	2019-09-01
卷号	75 期号:3 页码:821-830
关键词	generalized Behrens-Fisher hypothesis multivariate distributions nonparametrics rank statistics type I errors power of test
ISSN号	0006-341X
DOI	10.1111/biom.13029
英文摘要	Multiple endpoints are often naturally clustered based on their scientific interpretations. Tests that compare these clustered outcomes between independent groups may lose efficiency if the cluster structures are not properly accounted for. For the two-sample generalized Behrens-Fisher hypothesis concerning multiple endpointswe propose a cluster-adjusted multivariate test procedure for the comparison and demonstrate its gain in efficiency over test procedures that ignore the clusters. Data from a dietary intervention trial are used to illustrate the methods.
资助项目	Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health ; Intramural Research Program of the National Institutes of Health ; US Social Security Administration ; Special National Key Research and Development Plan[2016YFD0400206] ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600] ; National Nature Science Foundation of China[11722113]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000488608100010
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/35873]
专题	系统科学研究所
通讯作者	Li, Qizhai
作者单位	1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA 2.George Mason Univ, Dept Stat, Fairfax, VA 22030 USA 3.Natl Inst Hlth Clin Ctr, Rehabil Med Dept, Bethesda, MD USA 4.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Liu, Aiyi,Tang, Larry L.,et al. A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment[J]. BIOMETRICS,2019,75(3):821-830.
APA	Zhang, Wei,Liu, Aiyi,Tang, Larry L.,&Li, Qizhai.(2019).A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment.BIOMETRICS,75(3),821-830.
MLA	Zhang, Wei,et al."A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment".BIOMETRICS 75.3(2019):821-830.