Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes

doi:10.3389/fgene.2019.00252

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes
	Sun, Shaoyan 4; Sung, Fengnan 1; Wang, Yong2,3
刊名	FRONTIERS IN GENETICS
	2019-03-26
卷号	10 页码:16
关键词	type 2 diabetes gene pairwise expression dysfunctional interactions multi-level analysis random walk with restart
ISSN号	1664-8021
DOI	10.3389/fgene.2019.00252
英文摘要	Type 2 diabetes (T2D) is known as a disease caused by gene alterations characterized by insulin resistance, thus the insulin-responsive tissues are of great interest for T2D study. It's of great relevance to systematically investigate commonalities and specificities of T2D among those tissues. Here we establish a multi-level comparative framework across three insulin target tissues (white adipose, skeletal muscle, and liver) to provide a better understanding of T2D. Starting from the ranks of gene expression, we constructed the 'disease network' through detecting diverse interactions to provide a well-characterization for disease affected tissues. Then, we applied random walk with restart algorithm to the disease network to prioritize its nodes and edges according to their association with T2D. Finally, we identified a merged core module by combining the clustering coefficient and Jaccard index, which can provide elaborate and visible illumination of the common and specific features for different tissues at network level. Taken together, our network-, gene-, and module-level characterization across different tissues of T2D hold the promise to provide a broader and deeper understanding for T2D mechanism.
资助项目	National Key Research and Development Program of China[2017YFC0908400] ; NSFC[11871463] ; NSFC[61621003] ; NSFC[61671444]
WOS研究方向	Genetics & Heredity
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000462601100003
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/34274]
专题	应用数学研究所
通讯作者	Sun, Shaoyan; Wang, Yong
作者单位	1.Yantaishan Hosp, Clin Lab, Yantai, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS, Beijing, Peoples R China 4.Ludong Univ, Sch Math & Stat, Yenta, Peoples R China
推荐引用方式 GB/T 7714	Sun, Shaoyan,Sung, Fengnan,Wang, Yong. Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes[J]. FRONTIERS IN GENETICS,2019,10:16.
APA	Sun, Shaoyan,Sung, Fengnan,&Wang, Yong.(2019).Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes.FRONTIERS IN GENETICS,10,16.
MLA	Sun, Shaoyan,et al."Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes".FRONTIERS IN GENETICS 10(2019):16.