Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy

doi:10.1002/smll.201903254

	Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy
	Wang, Liying; Zhang, Tingting; Huo, Minfeng; Guo, Jia; Chen, Yu; Xu, Huixiong
刊名	SMALL
	2019-11-30
卷号	15 期号:47
关键词	DNA damage iridium nucleus-targeting photothermal radiotherapy
ISSN号	1613-6810
DOI	10.1002/smll.201903254
文献子类	Article
英文摘要	Prominent tumor-cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor-specific photonic hyperthermia-synergized radiotherapy. To endow the NCs with qualified cell nucleus-targeting performance, polyethylene glycol (PEG)-modified Ir NCs are decorated with alpha(v)beta(3) integrin-targeting cyclic arginine-glycine-aspartic (c(RGDyC)), designated as RGD, peptides and human immunodeficiency virus-1 transactivator of transcription protein(TAT), respectively, facilitating the tumor-cell-membrane (with overexpressed alpha(v)beta(3) integrin) and cell-nucleus targeting. The formulated Ir-RGD-TAT (Ir-R/T) NCs are demonstrated to accumulate inside the nucleus of tumor cells and generate effective DNA lesions upon X-ray irradiation. Further in vivo evaluations verify the satisfactory carcinoma destruction performance against 4T1 tumor xenografts. Importantly, the intriguing photonic NIR adsorption of Ir-R/T NCs has enabled the hyperthermia therapeutics accompanied with photoacoustic imaging modalities, achieving clinically promising biocompatible multifunctional radiosensitized nanoplatforms for effective tumor therapeutics.
WOS关键词	TOTAL MESORECTAL EXCISION ; TUMOR MICROENVIRONMENT ; RECEPTOR-BINDING ; RECTAL-CANCER ; NANOPARTICLES ; THERAPY ; DELIVERY ; GOLD ; GAMMA-H2AX ; RADIATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27534]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Wang, Liying,Zhang, Tingting,Huo, Minfeng,et al. Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy[J]. SMALL,2019,15(47).
APA	Wang, Liying,Zhang, Tingting,Huo, Minfeng,Guo, Jia,Chen, Yu,&Xu, Huixiong.(2019).Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy.SMALL,15(47).
MLA	Wang, Liying,et al."Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy".SMALL 15.47(2019).