Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis

doi:10.1002/adfm.201908365

	Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis
	Chen, Xiaoyan; Zhang, Huilin; Zhang, Meng; Zhao, Peiran; Song, Ruixue; Gong, Teng; Liu, Yanyan; He, Xinhong; Zhao, Kuaile; Bu, Wenbo
刊名	ADVANCED FUNCTIONAL MATERIALS
	2019-12-31
关键词	amorphous Fe-0 carbonic anhydrase IX chemodynamic therapy metastasis tumor acidosis
ISSN号	1616-301X
DOI	10.1002/adfm.201908365
文献子类	Article; Early Access
英文摘要	Chemodynamic therapy (CDT) by introducing the Fenton-/Fenton-like reaction in an acidic and H2O2 environment for toxic hydroxyl radical (center dot OH) generation, is a newly developed tumor-selective therapeutic. However, tumor acidosis, characterized by extracellular acidity (pH(e) approximate to 6.5) and intracellular alkalinity (pH(i) approximate to 7.2), undoubtedly confers a large chemical barrier for effective implementation of intracellular CDT and thus limits its functional activity and therapeutic efficacy. Here, the unique amorphous iron nanoparticles (AFeNPs) loaded with carbonic anhydrase IX inhibitor (CAI) are constructed to re-establish tumor acidosis with decreased pH(i) and increased pH(e) via inhibiting the over-expressed CA IX in cancer cells by CAI for self-enhanced CDT. The suppression of CA IX leads to H+ accumulation in cells that could accelerate the AFeNPs-based Fenton reaction to drastically exacerbate oxidative stress in cells and subsequently induce cell death; meanwhile, the inhibition of H+ formation outside cells efficiently represses the potential of tumor invasion and metastasis owing to the insufficient acidic ions for degradation of tumor extracellular matrix. Re-established tumor acidosis not only assists in the optimization of CDT, but also presents an opportunity for the development of new antitumor methods that are more tumor-acidity specific.
WOS关键词	CARBONIC-ANHYDRASE-IX ; NANOPARTICLES ; SULFONAMIDE ; METASTASIS ; EXPRESSION ; INHIBITORS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27470]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Chen, Xiaoyan,Zhang, Huilin,Zhang, Meng,et al. Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis[J]. ADVANCED FUNCTIONAL MATERIALS,2019.
APA	Chen, Xiaoyan.,Zhang, Huilin.,Zhang, Meng.,Zhao, Peiran.,Song, Ruixue.,...&Bu, Wenbo.(2019).Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis.ADVANCED FUNCTIONAL MATERIALS.
MLA	Chen, Xiaoyan,et al."Amorphous Fe-Based Nanoagents for Self-Enhanced Chemodynamic Therapy by Re-Establishing Tumor Acidosis".ADVANCED FUNCTIONAL MATERIALS (2019).