Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy

doi:10.1002/adma.201904011

	Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy
	Tang, Zhong-min; Liu, Yan-yan; Ni, Da-long; Zhou, Jia-jia; Zhang, Meng; Zhao, Pei-ran; Lv, Bin; Wang, Han; Jin, Da-yong; Bu, Wen-bo
刊名	ADVANCED MATERIALS
	2019-12-31
关键词	biodegradable nanoprodrugs MgO2 nanosheets molecular dynamic therapy tumor microenvironment
ISSN号	0935-9648
DOI	10.1002/adma.201904011
文献子类	Article; Early Access
英文摘要	Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic center dot OH to kill tumor cells.
WOS关键词	REACTIVE OXYGEN ; HYDROGEN-PEROXIDE ; GROWTH ; TRANSDUCTION ; MAGNESIUM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27455]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Tang, Zhong-min,Liu, Yan-yan,Ni, Da-long,et al. Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy[J]. ADVANCED MATERIALS,2019.
APA	Tang, Zhong-min.,Liu, Yan-yan.,Ni, Da-long.,Zhou, Jia-jia.,Zhang, Meng.,...&Bu, Wen-bo.(2019).Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy.ADVANCED MATERIALS.
MLA	Tang, Zhong-min,et al."Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy".ADVANCED MATERIALS (2019).