Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction

doi:10.1016/j.biomaterials.2018.12.012

	Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction
	Yu, Qingqing; Han, Yiming; Tian, Tian; Zhou, Quan; Yi, Zhengfang; Chang, Jiang; Wu, Chengtie
刊名	BIOMATERIALS
	2019-02-01
卷号	194 页码:25
关键词	Chinese sesame stick CaCuSi4O10 Scaffolds Tumor therapy Tissue reconstruction
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2018.12.012
文献子类	Article
英文摘要	Surgery is a common treatment to remove the solid skin tumors. It is of great importance to eliminate the remaining tumor cells and achieve the simultaneous tissue reconstruction after surgery for improving life quality of cancer patients. Inspired by the designing strategy and fabrication method of Chinese sesame sticks, a Chinese sesame stick-like scaffold is developed by spin coating of CaCuSi4O10 nanoparticles (NPs) on the surface of electrospun fibers for tumor therapy and skin tissue reconstruction. The CaCuSi4O10 NPs can transform near infrared light energy into heat energy, showing the photothermal conversion efficiency of 33.8%. After coating of the CaCuSi4O10 NPs on the fibers, the prepared scaffolds exhibit the Chinese sesame stick-like structure and achieve bifunction with both tumor killing and skin tissue reconstruction capacities. The CaCuSi4O10 NPs endow the scaffolds with photothermal ablation potential to rapidly kill the in vitro tumor cells. Furthermore, Chinese sesame stick-like scaffolds effectively inhibit in vivo tumor growth at the early stage and accelerate healing of cancer surgery-caused wounds at the later stage in tumor-bearing mice. Additionally, the composite scaffolds promote chronic wound healing by stimulating in vivo angiogenesis and re-epithelization, harnessing locally release of bioactive Cu2+ and SiO44- ions from the CaCuSi4O10 NPs. Therefore, the Chinese sesame stick-inspired scaffolds may lay a solid foundation for clinical treatment of cancers and cancer surgery-induced tissue damage.
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27366]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Yu, Qingqing,Han, Yiming,Tian, Tian,et al. Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction[J]. BIOMATERIALS,2019,194:25.
APA	Yu, Qingqing.,Han, Yiming.,Tian, Tian.,Zhou, Quan.,Yi, Zhengfang.,...&Wu, Chengtie.(2019).Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction.BIOMATERIALS,194,25.
MLA	Yu, Qingqing,et al."Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction".BIOMATERIALS 194(2019):25.