CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators

doi:10.1002/anie.201812272

	CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators
	Yu, Xujiang; Liu, Xinyi; Wu, Weijie; Yang, Kai; Mao, Rihua; Ahmad, Farooq; Chen, Xiaoyuan; Li, Wanwan
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-02-11
卷号	58 期号:7 页码:2017
关键词	computed tomography magnetic resonance imaging nanoscintillators radiotherapy X-ray inducible photodynamic therapy
ISSN号	1433-7851
DOI	10.1002/anie.201812272
文献子类	Article
英文摘要	The use of X-rays instead of UV/Vis light to trigger photodynamic therapy, named X-ray inducible photodynamic therapy, holds tremendous promise due to a high penetration capacity in tissues and is worthy of in-depth study. In this study, a novel multifunctional nanoagent based on Merocyanine 540-coupled Gd-2(WO4)(3):Tb nanoscintillators and the vitalization of its abilities for dual-modal computed tomography and the magnetic-resonance-imaging-guided synergistic radio-/X-ray inducible photodynamic therapy of tumors is reported. Synergistic therapies show a higher tumor growth inhibition efficiency at a lower X-ray dose than radiotherapy alone. Through this proof-of-concept work, a way to tactfully understand and utilize nanoscintillators for cancer theranostics is shown.
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27336]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Yu, Xujiang,Liu, Xinyi,Wu, Weijie,et al. CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(7):2017.
APA	Yu, Xujiang.,Liu, Xinyi.,Wu, Weijie.,Yang, Kai.,Mao, Rihua.,...&Li, Wanwan.(2019).CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(7),2017.
MLA	Yu, Xujiang,et al."CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.7(2019):2017.