Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing

doi:10.1021/acs.nanolett.9b00367

	Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing
	Wang, Xiaocheng; Ma, Bing; Xue, Jianmin; Wu, JinFu; Chang, Jiang; Wu, Chengtie
刊名	NANO LETTERS
	2019-03-01
卷号	19 期号:3 页码:2138
关键词	Black titania oxygen vacancies thermogel tumor therapy wound healing
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.9b00367
文献子类	Article
英文摘要	Current challenges in cutaneous tumor therapy are healing the skin wounds resulting from surgical resection and eliminating possible residual tumor cells to prevent recurrence. To address this issue, bifunctional biomaterials equipped with effective tumor therapeutic capacity for skin cancers and simultaneous tissue regenerative ability for wound closure are highly recommended. Herein, we report an injectable thermosensitive hydrogel (named BT-CTS thermogel) with the integration of nanosized black titania (B-TiO2-x, similar to 50 nm) nanoparticles into a chitosan (CTS) matrix. The B-TiO2-x nanocrystal exhibits a crystalline/amorphous core-shell structure with abundant oxygen vacancies, which endows the BT-CTS thermogels with simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT) effects under single-wavelength near-infrared laser irradiation, leading to an excellent therapeutic effect on skin tumors in vitro and in vivo. Moreover, the BT-CTS thermogel not only supports the adhesion, proliferation, and migration of normal skin cells but also facilitates skin tissue regeneration in a murine chronic wound model. Therefore, such BT-CTS thermogels with easy injectability, excellent thermostability, and simultaneous PTT and PDT efficacy as well as tissue regenerative activity offers a promising pathway for the healing of cutaneous tumor-induced wounds.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27301]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Wang, Xiaocheng,Ma, Bing,Xue, Jianmin,et al. Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing[J]. NANO LETTERS,2019,19(3):2138.
APA	Wang, Xiaocheng,Ma, Bing,Xue, Jianmin,Wu, JinFu,Chang, Jiang,&Wu, Chengtie.(2019).Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing.NANO LETTERS,19(3),2138.
MLA	Wang, Xiaocheng,et al."Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing".NANO LETTERS 19.3(2019):2138.