Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study

doi:10.1016/j.compositesb.2019.02.003

	Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study
	Guo, Jingshu; Su, Wei; Jiang, Jia; Ning, Congqin; Zhao, Jinzhong; Liu, Xuanyong
刊名	COMPOSITES PART B-ENGINEERING
	2019-05-15
卷号	165 页码:526
关键词	Composite film Melt-pressing technique Tendon to bone healing Rotator cuff tear
ISSN号	1359-8368
DOI	10.1016/j.compositesb.2019.02.003
文献子类	Article
英文摘要	High failure rate of tendon to bone healing after surgery has always been a challenging problem in rotator cuff repair. Considering the flexibility of PLLA and osteogenic activity of calcium phosphate silicate (CPS) ceramic, PLLA/CPS composite films were produced by a simple melt-pressing technique, the in vitro and in vivo biocompatibility and bioactivity were investigated. With an increase of CPS content, the adhesion and proliferation of cells on composite films were improved. The sample with a PLLA/CPS volume ratio of 5/1 (5P/C) showed a highest ALP activity expression. The in vivo results also revealed that the 5P/C composite sample had good biocompatibility and biodegradability, which could improve the organization of collagen and the formation of cartilage and bone. Moreover, the biomechanical test demonstrated that 5P/C group displayed the best mechanical performance among the three groups. 12 weeks after surgery, a well engineered tendon to bone interface was formed in the PLLA/CPS composite film case.
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27115]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Guo, Jingshu,Su, Wei,Jiang, Jia,et al. Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study[J]. COMPOSITES PART B-ENGINEERING,2019,165:526.
APA	Guo, Jingshu,Su, Wei,Jiang, Jia,Ning, Congqin,Zhao, Jinzhong,&Liu, Xuanyong.(2019).Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study.COMPOSITES PART B-ENGINEERING,165,526.
MLA	Guo, Jingshu,et al."Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study".COMPOSITES PART B-ENGINEERING 165(2019):526.