Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy

doi:10.1021/acsami.9b02905

	Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy
	Chen, Qian; Luo, Yu; Du, Wenxian; Liu, Zhuang; Zhang, Shengjian; Yang, Jiahui; Yao, Heliang; Liu, Tianzhi; Ma, Ming; Chen, Hangrong
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-05-22
卷号	11 期号:20 页码:18133
关键词	chemodynamic therapy photothermal therapy pH independent Fenton-like reaction clearance cancer theranostic
ISSN号	1944-8244
DOI	10.1021/acsami.9b02905
文献子类	Article
英文摘要	Chemodynamic therapy (CDT) is an emerging field, which utilizes intratumoral iron-mediated Fenton chemistry for cancer therapy. However, the slightly acidic tumor environment is improper for the classical Fenton reaction, which is generally energetic in a narrow pH range (e.g., pH = 3-4). Herein, a kind of ultrasmall bovine serum albumin (BSA)-modified chalcopyrite nanoparticles (BSA-CuFeS2 NPs) was synthesized via a facile aqueous biomineralization strategy, which shows high dispersity and biocompatibility. Interestingly, the obtained BSA-CuFeS2 shows a pH-independent Fenton-like reaction, which could exert Fenton-like activity to efficiently generate (OH)-O-center dot under a weak acidic tumor environment. Combined with the extraordinarily high photothermal conversion (38.8%), BSA-CuFeS2 shows the synergistic function of high photothermal therapy (PTT) and enhanced CDT, that is, PTT/CDT. Importantly, such ultrasmall BSA-CuFeS2 NPs measuring around 4.9 nm can be quickly cleared out of the body through kidneys and liver, thus effectively avoiding long-term toxicity and systemic toxicity. Moreover, BSA-CuFeS2 NPs can act as an efficient T-2-weighted magnetic resonance imaging (MRI) contrast agent to guide tumor ablation in vivo. This work offers a universal approach to boost production (OH)-O-center dot by a pH-independent Fenton-like reaction strategy and achieves MRI-guided synergistic enhanced photothermal-CDT for highly efficient tumor treatment.
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27107]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Chen, Qian,Luo, Yu,Du, Wenxian,et al. Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(20):18133.
APA	Chen, Qian.,Luo, Yu.,Du, Wenxian.,Liu, Zhuang.,Zhang, Shengjian.,...&Chen, Hangrong.(2019).Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(20),18133.
MLA	Chen, Qian,et al."Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.20(2019):18133.