The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating

doi:10.1016/j.msec.2019.04.009

	The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating
	Li, Kai; Lu, Xiang; Razanau, Ihar; Wu, Xiaodong; Hu, Tao; Liu, Shiwei; Xie, Youtao; Huang, Liping; Zheng, Xuebin
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2019-08-01
卷号	101 页码:513
关键词	Angiogenesis Endothelial cells Boron Calcium silicate coating Coating extract
ISSN号	0928-4931
DOI	10.1016/j.msec.2019.04.009
文献子类	Article
英文摘要	Early vascularization is crucial for osteogenic repair of bone defects and plays an essential role in the fate of implanted biomaterials. Thus, there is a growing interest in the use of biomaterials to release inorganic ions that are capable of stimulating angiogenesis. Since it has been established that boron (B) may play roles in angiogenesis, the aim of our study was to investigate the in vitro angiogenic effects of the ionic dissolution products from the B-incorporated calcium silicate (Ca11Si4B2O22, B-CS) coating. The results showed that ionic products of B-CS coating extract obviously stimulated the proliferation and migration of human umbilical vein endothelial cells (HUVECs) as well as the in vitro tubule formation when compared with those of CS coating extract. In addition, the gene expression levels of pro-angiogenic growth factors (VEGF, bFGF, ANG1) and receptors (VEGFR-2, bFGFR) were significantly upregulated when stimulated with the B-CS coating extract. Moreover, VEGF and VEGFR-2 protein synthesis, eNOS, and Akt phosphorylation, as well as NO synthesized by HUVECs were increased by the B-CS coating extract. Hence, the B-CS coating offers a potential solution to enhance bone vascularization essential for successful osseointegration of orthopedic implants.
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26944]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Li, Kai,Lu, Xiang,Razanau, Ihar,et al. The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,101:513.
APA	Li, Kai.,Lu, Xiang.,Razanau, Ihar.,Wu, Xiaodong.,Hu, Tao.,...&Zheng, Xuebin.(2019).The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,101,513.
MLA	Li, Kai,et al."The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 101(2019):513.