Solving mazes with single-molecule DNA navigators

doi:10.1038/s41563-018-0205-3

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Solving mazes with single-molecule DNA navigators
	Chao, J ; Wang, JB ; Wang, F ; Ouyang, XY ; Kopperger, E ; Liu, HJ ; Li, Q ; Shi, JY ; Wang, LH ; Hu, J
刊名	NATURE MATERIALS
	2019
卷号	18 期号:3 页码:273—+
关键词	PLASMONIC NANOSTRUCTURES DESIGN WALKER COMPUTATION TRANSPORT DNAZYME NETWORK ROBOTS
ISSN号	1476-1122
DOI	10.1038/s41563-018-0205-3
文献子类	期刊论文
英文摘要	Molecular devices with information-processing capabilities hold great promise for developing intelligent nanorobotics. Here we demonstrate a DNA navigator system that can perform single-molecule parallel depth-first search on a ten-vertex rooted tree defined on a two-dimensional DNA origami platform. Pathfinding by the DNA navigators exploits a localized strand exchange cascade, which is initiated at a unique trigger site on the origami with subsequent automatic progression along paths defined by DNA hairpins containing a universal traversal sequence. Each single-molecule navigator autonomously explores one of the possible paths through the tree. A specific solution path connecting a given pair of start and end vertices can then be easily extracted from the set of all paths taken by the navigators collectively. The solution path laid out on origami is illustrated with single-molecule imaging. Our approach points towards the realization of molecular materials with embedded computational functions operating at the single-molecule level.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31822]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai, Peoples R China; 2.Nanjing Univ Posts & Telecommun, IAM, KLOEID, Nanjing, Jiangsu, Peoples R China; 3.Nanjing Univ Posts & Telecommun, Sch Mat Sci & Engn, Nanjing, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai, Peoples R China; 7.Shanghai Jiao Tong Univ, Joint Res Ctr Precis Med, Affiliated Peoples Hosp 6, Shanghai Fengxian Cent Hosp, South Campus, Shanghai, Peoples R China; 8.Tech Univ Munich, Phys Dept, Phys Synthet Biol Syst E14, Garching, Germany; 9.Tongji Univ, Sch Chem Sci & Engn, Shanghai, Peoples R China; 10.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Chao, J,Wang, JB,Wang, F,et al. Solving mazes with single-molecule DNA navigators[J]. NATURE MATERIALS,2019,18(3):273—+.
APA	Chao, J.,Wang, JB.,Wang, F.,Ouyang, XY.,Kopperger, E.,...&Fan, CH.(2019).Solving mazes with single-molecule DNA navigators.NATURE MATERIALS,18(3),273—+.
MLA	Chao, J,et al."Solving mazes with single-molecule DNA navigators".NATURE MATERIALS 18.3(2019):273—+.