Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy

doi:10.1039/c8an02079e

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy
	Zhu, ZJ ; Cheng, C ; Chang, C ; Ren, GH ; Zhang, JB ; Peng, Y ; Han, JG ; Zhao, HW
刊名	ANALYST
	2019
卷号	144 期号:8 页码:2504—2510
关键词	LOW-FREQUENCY VIBRATIONS RAMAN-SPECTROSCOPY MODES ACID
ISSN号	0003-2654
DOI	10.1039/c8an02079e
文献子类	期刊论文
英文摘要	The neurotransmitter norepinephrine (NE) was investigated by broadband terahertz time-domain spectroscopy (THz-TDS) in the air-plasma system range from 0.5 to 18.2 THz. NE has a unique absorption spectrum in the THz band, which can be used as a characteristic fingerprint for molecular detection and identification. The temperature-dependent THz spectra of NE were recorded in the range from 83 to 293 K, and a blue-shift of the absorption peaks was observed as the temperature decreased. A solid-state density functional theory (DFT) calculation was implemented to better understand the low-frequency vibrational property of NE, and the calculated results agree well with the THz experimental observations. This result suggests that the broadband THz system can obtain more abundant spectral signals of NE and each THz resonance peak has its own specific vibrational mode, which corresponds to a specific structure and interaction. Even with the adjacent absorption peaks, the vibrational behaviors are different. The deformation of the aromatic ring and the flexibility of the side chain directly affect the NE molecular conformation, which may be closely associated with the receptor binding preference for the neurotransmitter. The conformational diversity of NE may help to understand the biological function of the neurotransmitter in the nervous system.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31502]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Adv Res Inst, 99 Haike Rd,Zhanjiang Hitech Pk, Shanghai 201210, Peoples R China; 5.Natl Innovat Inst Def Technol, Adv Interdisciplinary Technol Res Ctr, Beijing 100071, Peoples R China; 6.Tianjin Univ, Minist Educ, Ctr Terahertz Waves, Tianjin 300072, Peoples R China; 7.Tianjin Univ, Minist Educ, Coll Precis Instrument & Optoelect Engn, Tianjin 300072, Peoples R China; 8.Tianjin Univ, Minist Educ, Key Lab Optoelect Informat & Technol, Tianjin 300072, Peoples R China; 9.Univ Shanghai Sci & Technol, Shanghai Key Lab Modern Opt Syst, 516 Jungong Rd, Shanghai 200093, Peoples R China
推荐引用方式 GB/T 7714	Zhu, ZJ,Cheng, C,Chang, C,et al. Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy[J]. ANALYST,2019,144(8):2504—2510.
APA	Zhu, ZJ.,Cheng, C.,Chang, C.,Ren, GH.,Zhang, JB.,...&Zhao, HW.(2019).Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy.ANALYST,144(8),2504—2510.
MLA	Zhu, ZJ,et al."Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy".ANALYST 144.8(2019):2504—2510.