3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey

doi:10.1021/acs.inorgchem.8b03442

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey
	Wang, XM ; Wu, SQ ; Guan, JW ; Chen, LH ; Sho, C ; Wan, JM ; Liu, Y ; Juan, DW ; Wang, JQ ; Wang, SA
刊名	INORGANIC CHEMISTRY
	2019
卷号	58 期号:5 页码:3349—3354
关键词	MULTIDENTATE CATECHOLATE SEQUESTERING AGENTS DESILYLATION METHOD NITRATE COMPLEXES TOXICITY URANIUM PYRROLIDINE DEFERIPRONE PIPERIDINE DESIGN
ISSN号	0020-1669
DOI	10.1021/acs.inorgchem.8b03442
文献子类	期刊论文
英文摘要	Uranium poses a threat for severe renal and bone damage in vivo. With the rapid development of nuclear industry, it is more urgent than ever to search for potential in vivo uranium chelators. In this work, 3-hydroxy-2-pyrrolidinone (HPD) is investigated as a new potential uranium decorporation ligand. The potentiometric titration measurements were carried out, and the stability constants were determined to be log beta(110) = 10.5(7), log beta(120) = 20.7(9), and log beta(130) = 28.2(4). The species distribution diagram shows that nearly all uranyl is complexed by HPD at pH 7.4 under the defined condition. A single crystal of uranyl and HPD complexes, [(UO2)(3)O(H2O)(3)(C4H6NO2)(3)]center dot NO3 center dot 12H(2)O (uranyl-HPD), was obtained via an evaporation method. The overall structure of uranyl-HPD is a trimer that consists of three uranyl units and three HPD ligands. The uranyl unit is equatorially coordinated by three oxygen atoms from two HPD agents, one coordinated water molecule, and one mu(3)-O atom that is shared by three uranyl units. The results of the cytotoxicity assay indicate that the ligand is less toxic than the chelators used clinically (i.e., DTPA-ZnNa3 and 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (DFP)). The results of the uranium removal assay using the NRK-52E cell show that it could reduce as much as 58% of the uranium content at the cellular level. Furthermore, the in vivo uranium decorporation assays demonstrate that HPD can remove 52% of uranium deposited in the kidney but shows poor uranium removal efficacy in the bone.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31443]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Shanghai 201800, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 210049, Peoples R China; 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China; 4.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China; 5.Univ South China, Acad Environm Protect & Safety Engn, Hengyang 421001, Peoples R China
推荐引用方式 GB/T 7714	Wang, XM,Wu, SQ,Guan, JW,et al. 3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey[J]. INORGANIC CHEMISTRY,2019,58(5):3349—3354.
APA	Wang, XM.,Wu, SQ.,Guan, JW.,Chen, LH.,Sho, C.,...&Wang, SA.(2019).3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey.INORGANIC CHEMISTRY,58(5),3349—3354.
MLA	Wang, XM,et al."3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey".INORGANIC CHEMISTRY 58.5(2019):3349—3354.